Emma Josefsson-Publications

Emma Josefsson-Publications

Researcher: 

Selected publications

  1. Lebois M, Dowling MR, Gangatirkar P, Hodgkin PD, Kile BT, Alexander WS, Josefsson EC. Regulation of platelet lifespan in the presence and absence of TPO signaling. J Thromb Haemost. 2016 Jun 25. doi: 10.1111/jth.13397. PMID: 27344013
  2. Lebois M, Josefsson EC. Regulation of platelet lifespan by apoptosis. Platelets. 2016 Apr 21:1-8. [Epub ahead of print] PubMed PMID: 27100842
  3. Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, Kile BT, Josefsson EC. BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death Disease. 2015 Apr 16;6:e1721. doi: 10.1038/cddis.2015.97. PMID: 25880088
  4. Josefsson, EC, Burnett, DL, Lebois, M, Debrincat, MA, White, MJ, Henley, KJ, Lane, RM, Moujalled, D, Preston, SP, O'Reilly, LA, Pellegrini, M, Metcalf, D, Strasser, A & Kile, BT Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nature Communications. 2014.5, 3455 doi: 10.1038/ncomms4455 PMID: 24632563
  5. *Debrincat MA, *Josefsson EC, *James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT. Mcl-1 and Bcl-xL co-ordinately regulate megakaryocyte survival. Blood. 2012 119(24):5850-8 PMID: 22374700. *Joint First Authors
  6. *Jansen AJ, *Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. Blood. 2012 119(5):1263-73. PMID: 22101895. *Joint First Authors
  7. Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. The Journal of Experimental Medicine. 2011 208(10):2017-31. PMID: 21911424
  8. *Dowling MR, *Josefsson EC, Henley KJ, Hodgkin PD, Kile BT. Platelet senescence is regulated by an internal timer, not damage inflicted by hits. Blood. 2010 116(10):1776-8. PMID: 20530288. *Joint First Authors
  9. Rumjantseva V, Grewal PK, Wandall HH, Josefsson EC, Sørensen AL, Larson G, Marth JD, Hartwig JH, Hoffmeister KM. Dual roles for hepatic lectin receptors in the clearance of chilled platelets. Nature Medicine. 2009 15(11):1273-80. PMID: 19783995.
  10. Schoenwaelder SM, Yuan Y, Josefsson EC, White MJ, Yao Y, Mason KD, O'Reilly LA, Henley KJ, Ono A, Hsiao S, Willcox A, Roberts AW, Huang DC, Salem HH, Kile BT, Jackson SP. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood. 2009 114(3):663-6. PMID: 19387006.

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