Ian Majewski-Projects

Ian Majewski-Projects

Researcher: 

Projects

Disease progression in lymphoma

We are studying the molecular alterations that drive disease progression in patients with lymphoid malignancies, with a particular focus on follicular lymphoma and chronic lymphocytic leukaemia (CLL).

In collaboration with Professor Andrew Roberts we are studying the selective pressures that operate in lymphoma and investigating genetic and epigenetic factors that influence response to the newest therapies available for CLL, including small molecule inhibitors of BCL2.

Improving the diagnosis and clinical management of childhood leukaemia

Together with Professor Paul Ekert and Dr Alicia Oshlack we are applying RNA sequencing to improve the diagnosis and clinical management of childhood leukaemia.

We are developing new methods to profile the transcriptome to identify cancer-specific changes, including the detection of structural alterations, translocations, altered mRNA processing and mutational profiling.

Identifying key driver genes in acute myeloid leukaemia

Over the past ten years we have gained tremendous insight into the genes that drive acute myeloid leukaemia (AML), yet many questions remain regarding how these mutations alter the biology of the disease.

We are using genomic and transcriptional profiling to define genes that influence therapy response in patients with core-binding factor AML.