Nicos Nicola-Projects

Nicos Nicola-Projects

Projects

JAK/STAT/SOCS signalling in myeloproliferative neoplasms

We aim to determine the roles of receptor/JAK scaffolds as signaling platforms for disease initiation and maintenance. We also want to determine if SOCS proteins alleviate disease pathology and if they can be used to dissect the relative contribution of mutant and wild-type JAK alleles to disease symptoms.

A new class of negative regulators of cytokine signalling

We recently identified MARCH proteins as potential negative regulators of cytokine signalling.  We aim to determine the specificity of their actions in terms of cytokine and molecular targets and their mechanism of action. We also aim to determine their roles in vivo using genetic deletion experiments.