Cytokine control of blood cell function in health and disease

Cytokine control of blood cell function in health and disease

Project details

Leukaemia and lymphoma are cancers of the blood and bone marrow that arise when the normal processes of blood cell production are disturbed. Cytokines are intercellular messengers that bind to specific receptors on the cell surface and affect cell proliferation, differentiation and apoptosis. Production of mature blood cells from haematopoietic stem cells is a tightly regulated process, and is controlled by many different cytokines. 

In this project, the molecular mechanisms of cytokine control of blood cell production and function will be examined, with an emphasis on the negative regulation of cytokine signaling by the suppressor of cytokine signaling (SOCS) proteins. Understanding the role of these proteins in the blood may lead to new treatment strategies for blood cancers.

 

About our research group

Our research group seeks to understand the molecular mechanisms of blood cell production and function, and how changes in these processes can lead to blood disorders and malignancies. 

We have many years’ experience in studying the function of cytokines and their negative regulators in the haematopoietic system, using a range of molecular and cell biology techniques, including quantitative PCR, genomics, immunoblotting, FACS and proteomics

Publications relevant to this project include: White, C.A. and Nicola, N.A. JAK-STAT. 2013;4(2):e25045, Babon, J.J. J Mol Biol. 2009;387:162-174 and Croker, B.A. et al. Nat Immunol. 2003;4:540-545.  

 

Researchers:

Professor Warren Alexander

Professor Warren Alexander in the lab
Professor
Warren
Alexander
Joint Division Head
Dr Christine White profile photo
Dr
Christine
White
Cancer and Haematology division

Project Type: