Deciphering mechanisms of thrombocytopenia (low platelet count) in blood cancers

Deciphering mechanisms of thrombocytopenia (low platelet count) in blood cancers

Project details

Leukaemia and lymphoma patients develop thrombocytopenia, and increased risk of bleeding. The mechanism of thrombocytopenia in blood cancer remains elusive (Li, Leukemia 2016 30(3):536-44). Reduction in platelet numbers is also a common side effect of chemotherapy treatments and impacts cancer therapy (Kuter, Oncology 2015 29(4):282-94). 

This project will examine mechanisms of thrombocytopenia in haematological malignancy. This could lead to therapeutic strategies to restore platelet number and enable optimal chemotherapy.

About our research group

Our laboratory is interested in understanding the molecular pathways that regulate platelet production and function in health and disease. We recently characterised in detail the intrinsic and extrinsic apoptotic machinery in megakaryocytes (Josefsson, Nat Commun 2014 5(3455), Josefsson, J Exp Med 2011 208(10):2017). Another interest in our laboratory lies in better understanding the role of platelets in cancer progression. 

Researchers:

Dr Emma Josefsson

Dr Emma Josefsson
Dr
Emma
Josefsson
Laboratory Head

Project Type: