Determining the requirements for T cell memory

Determining the requirements for T cell memory

Project details

The cells of our immune system are uniquely positioned to enhance cellular interactions and effector responses. The factors that determine the retention of memory T cells within lymphoid organs are not fully understood, but this may be influenced by infection route, and differences in viral replication and tropism.

We have developed novel systems to determine the requirements of T cell memory positioning following different viral infection. Identifying the factors that regulate T cell memory positioning will inform strategic vaccine design.

Techniques to be used: 

  • Imaging to identify unique T cell memory positioning following viral infection
  • In vitro and in vivo characterisation of migration signals and cellular interactions using time-lapse imaging
  • Flow cytometry and bioinformatic and proteomic analysis

About our research group

Our immune system consists of specialised cells that collaborate to defeat invading pathogens. The integration of migration signals helps balance protective and detrimental fates, leading to protection from infection or promotion of autoimmune disease. How cells navigate these interactions is a dilemma of critical importance to human health globally.

Our lab studies how cell migration and interactions allow our immune system to function efficiently and how this is altered in autoimmune disease. We use a multi-disciplinary approach combining infectious and autoimmune models, advanced imaging, bioinformatic analysis, and molecular screening to dissect the migration networks that control cell fate and function. These cutting-edge approaches allow us to identify new targets for the strategic design of vaccines and therapies for infectious and inflammatory disease.

Researchers:

Dr Joanna Groom

Dr Joanna Groom outside a lab
Dr
Joanna
Groom
Laboratory Head
Dr Fanny Lafouresse profile shot
Dr
Fanny
Lafouresse
Immunology and Molecular Immunology divisions

Project Type: