Novel real-time, quantitative imaging approaches for studying malaria

Novel real-time, quantitative imaging approaches for studying malaria

Project details

Real-time visualisation and computational analysis of how malaria infects red blood cells will help guide vaccine and drug development. However, live cell and quantitative microscopy approaches remain a significant challenge due to the small size of the parasite and because host cell interactions are highly dynamic. 

This project aims to combine the use of novel fluorescent probes coupled with the most cutting edge microscopy techniques to overcome existing limitations. It would suit students with a strong interest in applying engineering principles or computer programming for improving the capture and analysis of multi-parametric datasets. 

New insights gained about malaria biology at the blood cell stage of the malaria life cycle will significantly impact on the prevention and treatment of this major global health problem.

 

About our research group

The Centre for Dynamic Imaging is a research-based technology platform for researchers at the institute who need access to cutting edge fluorescence microscopy techniques. Our interdisciplinary team develops and applies live cell imaging and automated image analysis routines that are tailored to studies on host-pathogen interactions, immune disorders and cancer. A major goal of our lab is to automate the capture of biological imaging data and provide a basis for more robust quantitative analyses.

Professor Alan Cowman leads a large malaria research group at the Institute and has made many contributions to understanding the biology of the malaria parasite and how it invades red blood cells.

Further reading:
Volz, Yap, Siquella et al.. Essential role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum invasion of erythrocytes. Cell Host & Microbe, 2016, 20(1):60-71.
Riglar et al. Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion. J Cell Sci. 2016, 129(1):228-242. 

Researchers:

Dr Kelly Rogers

Dr Kelly Rogers
Dr
Kelly
Rogers
Head, Imaging Laboratory

Professor Alan Cowman

Professor Alan Cowman in the lab
Professor
Alan
Cowman
Deputy Director and Joint Division Head
Dr Lachlan Whitehead
Dr
Lachlan
Whitehead
Systems Biology and Personalised Medicine division

Project Type: