A novel role for Mind Bomb-2 (MIB2) in cell death and inflammation

A novel role for Mind Bomb-2 (MIB2) in cell death and inflammation

Project details

Cell death is often inhibited in cancer, but can also be pathologically activated to cause autoinflammatory diseases. We have previously shown how programmed cell death is tuned by E3 ligase enzymes, which modify protein targets with ubiquitin chains to either activate, or inhibit, their signalling potential (reviewed in Feltham et al., IUBMB Life, 2012).

Using cancer cell lines we recently defined a novel role for the E3 ligase, Mind Bomb-2 (MIB2), in inhibiting programmed cell death caused by the inflammatory cytokine TNF, and its signalling component RIPK1 (Feltham et al., submitted). 

Using CRISPR/Cas9 gene editing technology, this project will now examine the substrates and physiological role of MIB2 under conditions of MIB2 deficiency or inactivation in several disease models, such as cancer, sepsis and arthritis

About our research group

We have a strong interest in studying how ubiquitin ligases function to regulate signalling pathways that lead to cell death and inflammation. We have many tools to interrogate cell death and inflammatory signalling pathways both in vitro and in vivo and are well equipped to study the consequences of perturbing these pathways in the context of a gene knockout models.

Researchers:

Dr Rebecca Feltham profile photo
Dr
Rebecca
Feltham
Inflammation division

Dr James Vince

Dr James Vince in a laboratory
Dr
James
Vince
Laboratory Head

Project Type: