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Partnering opportunities

Bridging the gap between laboratory discoveries and commercial innovation

WEHI has research projects in cancer, immunology and infectious diseases, feeding into our robust discovery and development pipeline. We are committed to the translation of our discoveries into improvements in disease diagnosis, prevention and treatment.

Project name Theme Stage Modality
Hit-to-Lead Cell therapy
Hit-to-Lead Small molecule
Hit discovery Small molecule
Target validation Biologic
Target Validation Gene therapy
Lead Optimisation Biologics
Hit discovery Biologic
Hit discovery RNA technology
Target Validation Small molecule
Target validation RNA technology
Proof of concept Reagent
Target Validation Biologics
Lead optimisation Small molecule
Hit discovery Biologic
Pilot system Diagnostic
β-prototype Diagnostic
α-prototype Diagnostic
Lead Optimisation Small molecule
Hit-to-Lead Small molecule
Target validation Small molecule
Target validation Small molecule
Target validation Small molecule
β-prototype Device
Colourful scientific image from Art of Science 2023

Active Projects

Cancer

Next generation DC therapy

A DC subset with superior antigen-presenting capability, engineered with a proprietary CAR design for immunotherapy.

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Stage
Hit-to-Lead
Theme
Cancer
Project contact
Ewa Michalak
michalak.e@wehi.edu.au

New target for MYC-driven cancers

Stage
Hit-to-Lead
Theme
Cancer
Project contact
David Segal
segal@wehi.edu.au

Small molecule inhibitor for blood cancer

Stage
Hit discovery
Theme
Cancer
Project contact
Ewa Michalak
michalak.e@wehi.edu.au

EphA10 bispecific antibody for solid tumours

Stage
Target validation
Theme
Cancer
Project contact
Ewa Michalak
michalak.e@wehi.edu.au

APOBEC gene editing

Delivery of a cancer-selective mRNA therapeutic that targets APOBEC enzymes.

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Stage
Target Validation
Theme
Cancer
Project contact
Ewa Michalak
michalak.e@wehi.edu.au

Immunology and inflammation

A therapy for haemolytic disease

A new therapy for global prevention of hemolytic disease of the newborn

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Stage
Lead Optimisation
Theme
Immunology and inflammation
Project contact
Onisha Patel
patel.o@wehi.edu.au

Blocking NINJ1

Developing a first-in-class, anti-NINJ1 therapy for cell death associated diseases.

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Stage
Hit discovery
Theme
Immunology and inflammation
Project contact
Onisha Patel
patel.o@wehi.edu.au

RNA-based gene therapy

Targeting inflammatory cytokine signalling in autoimmune disease

Download PDF
Stage
Hit discovery
Theme
Immunology and inflammation
Project contact
Onisha Patel
patel.o@wehi.edu.au

Targeting c-Rel

Degradation of c-Rel for treating chronic autoimmune inflammatory disease.

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Stage
Target Validation
Theme
Immunology and inflammation
Project contact
Onisha Patel
patel.o@wehi.edu.au

Targeting lung macrophages

Stage
Target validation
Theme
Immunology and inflammation
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

HaemaTONIC

A media cocktail and culture system for in vitro human haematopoiesis.

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Stage
Proof of concept
Theme
Immunology and inflammation
Project contact
Onisha Patel
patel.o@wehi.edu.au

Improving T cell memory

Method to induce stem-like memory T cells for long-lived response in vaccine design

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Stage
Target Validation
Theme
Immunology and inflammation
Project contact
Onisha Patel
patel.o@wehi.edu.au

Global health and infection

VirDUB – targeting PLPro

Oral therapeutic targeting coronavirus Mpro; potential to minimise progression to severe disease and post-acute sequelae of COVID-19 (PASC / Long COVID).

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Stage
Lead optimisation
Theme
Global health and infection
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

Antibacterial therapeutics

Stage
Hit discovery
Theme
Global health and infection
Project contact
David Segal
segal@wehi.edu.au

TrueSAT test

Stage
Pilot system
Theme
Global health and infection
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

Malaria screening test

A high throughput diagnostic for relapsing liver malaria.

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Stage
β-prototype
Theme
Global health and infection
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

P. vivax diagnostic

A high-throughput laboratory-based diagnostic for detecting hidden or cryptic liver stage Plasmodium vivax infections.

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Stage
α-prototype
Theme
Global health and infection
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

VirPRO – targeting Mpro

Oral therapeutic targeting diverse coronavirus PLpros; potential to minimise progression to severe disease and post-acute sequelae of COVID-19 (PASC / Long COVID).

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Stage
Lead Optimisation
Theme
Global health and infection
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

Neurological disorders

Precision epigenetics

Using an epigenetic approach to turn on genes, the absence of which causes Prader Willi Syndrome, a devistating neurodevelopment disorder

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Stage
Hit-to-Lead
Theme
Neurological disorders
Project contact
Jerome Wielens
wielens.j@wehi.edu.au

Bax in Parkinson’s disease

Stage
Target validation
Theme
Neurological disorders
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

Parkin activator and Parkinson’s disease

Stage
Target validation
Theme
Neurological disorders
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

Glycogen Ubiquitination

Stage
Target validation
Theme
Neurological disorders
Project contact
Victoria Jameson
jameson.v@wehi.edu.au

Platform technologies

Plunge Uino

An effective and affordable plunge freezing device for cryogenic electron microscopy.

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Stage
β-prototype
Theme
Platform technologies
Project contact
Seth Jones
jones.se@wehi.edu.au
Contact us

To discuss partnering opportunities and collaborations please contact our team.

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