Dr Alison Farley - Epigenetics & Development division

Dr Alison Farley - Epigenetics & Development division

Location: 
Davis Auditorium
Start Time: 
Wed, 01/12/2021 - 1:00pm
End Time: 
Wed, 01/12/2021 - 2:00pm

WEHI Wednesday Seminar hosted by Dr Samir Taoudi

Dr Alison Farley

Senior Research Officer - Taoudi Lab, Epigenetics & Development division - Healthy Development & Ageing Theme, WEHI

Mapping hemorrhagic stroke through development as a consequence of thrombocytopenia

 

Davis Auditorium

Online access via Slido and enter code #WEHIWEDNESDAY

Including Q&A session

 

Severe thrombocytopenia is a major clinical problem, it affects 1 in 2000 live births, 30 % of babies admitted to neonatal intensive care units, and 70% of babies with extremely low birth weight.  Severe thrombocytopenia can occur for many reasons but is most commonly caused by fetal and neonatal alloimmune thrombocytopenia.   The main complication of fetal and neonatal thrombocytopenia is intra-cerebral hemorrhage (ICH) which carries significant risk of life-long morbidities and death but a causative role of thrombocytopenia leading to ICH was unknown.

Using two different models of severe thrombocytopenia, I will talk about how we demonstrate that platelets are required throughout fetal development and into neonatal life to maintain the integrity of the cerebral vasculature to prevent ICH.  I will describe how we can  manipulate the thrombocytopenic range and as a consequence the severity of  ICH which could have clinical implications when understanding which thrombocytopenic neonates require platelet transfusion. 



All welcome!