Dr Charlene Magtoto - Ubiquitin Signalling division

Dr Charlene Magtoto - Ubiquitin Signalling division

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Start Time: 
Mon, 10/05/2021 - 11:00am
End Time: 
Mon, 10/05/2021 - 11:30am

WEHI Postgraduate Lecture series hosted by Dr Brad Sleebs


Dr Charlene Magtoto

Research Officer, Feltham Lab, Ubiquitin Signalling division, Healthy Development & Ageing Theme, WEHI


Protect and PROTAC: exploiting ubiquitin ligases for targeted protein degradation


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Including Q&A session



Targeted protein degradation is a technique that hijacks ubiquitin ligase machinery to ubiquitinate and degrade a protein of interest through the use of small molecule binders. The ability to study the functional consequences of protein loss in a rapid and reversible manner has several advantages over genetic modifications and small molecule inhibitors, which often exhibit off-target effects or are limited to catalytic proteins. In this seminar, I will provide an overview of targeted protein degradation with a focus on tag-Targeting Protein Degraders (tTPDs), or PROTACs, highlighting how they have become invaluable tools for the preclinical evaluation of therapeutic targets. 


Dr Charlene Magtoto is a Postdoctoral Research Fellow in the Feltham Laboratory at the WEHI. She is interested in determining the functionality and diversity of tTPDs in vivo. The increasing use of targeted protein degradation as a mode of preclinical therapeutic target validation holds several caveats surrounding tissue specificity, treatment duration, and optimal dosing. Using novel murine models, she aims to establish a comprehensive guide to in vivo tTPD and hopes to further improve these systems by manipulating other aspects of protein degradation machinery.



All welcome!