Dr Edward Chew, Blood Cells & Blood Cancer division

Dr Edward Chew, Blood Cells & Blood Cancer division

Location: 
Online
Start Time: 
Mon 23/11/2020 - 15:00 PM
End Time: 
Mon 23/11/2020 - 16:00 PM
Dr Edward Chew
PhD Student - Majewski & Roberts Labs, Blood Cells & Blood Cancer division - Cancer Research & Treatments Theme

MBD4 - a tale of blood and guts

WEHI PhD Completion Seminar hosted by Associate Professor Ian Majewski

 

A variety of repair mechanisms has evolved to protect our genome from damage. A ubiquitous form of DNA damage occurs from the spontaneous deamination of methylated cytosines, changing them to thymines. MBD4, a DNA glycosylase, plays a crucial role in the repair of this methylation damage.

The importance of MBD4 is highlighted in our discovery that congenital loss of MBD4 predisposes to acute myeloid leukaemia (AML). AMLs with MBD4 deficiency have a unique mutational profile and similar driver mutations with a key feature being early inactivation of DNMT3A. Our results reveal a mechanism whereby age-related DNA damage initiates clonal expansions in the blood and ultimately results in AML. MBD4 loss also affects the mutational profile of other cancers, suggesting an importance beyond AML.

Edward is a haematologist undertaking a PhD with Professor Andrew Roberts and Associate Professor Ian Majewski. He is using genomics to study the origin of AML and its subsequent resistance to therapy. He is supported by a Leukaemia Foundation (Clinical) Scholarship.

 

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Includes Q&A session