Dr Niall Geoghegan, Advanced Technology and Biology division

Dr Niall Geoghegan, Advanced Technology and Biology division

Start Time: 
Wed, 24/02/2021 - 1:00pm
End Time: 
Wed, 24/02/2021 - 2:00pm

Dr Niall Geoghegan
Research Officer – Rogers Laboratory, Centre for Dynamic Imaging, Advanced Technology & Biology division - New Medicines & Advanced Technologies Theme

If a picture is worth 1000 words, how much is a movie worth? Discovering new biology in 4-Dimensions

WEHI Wednesday seminar hosted by Dr Kelly Rogers


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Includes Q&A session


Technological advances can occur iteratively or with a stepwise shift. In the context of live cell imaging, Lattice Light-Sheet microscopy (LLSM) demonstrates such a stepwise shift. Originally published in 2014 the system has offered unprecedented insights into the subcellular world, spanning almost all aspects of cell biology.

Niall joined WEHI in 2016 to construct and implement WEHI's LLSM capabilities before a viable commercial option was available. Through partnership with HHMI Janelia Research Campus the institute was able to capitalise on this ground-breaking technology before much of the rest of the world. In the time since 2016, Niall has worked with numerous labs across the institute to visualise the diverse biology of WEHI’s researchers with previously unattainable spatial and temporal resolution in 4-dimensions.

In this talk Niall will tell the story of the technology, its journey from invention to the bench and how this has led to new discoveries in the ways that cells die and how parasites enter the host cellular environment.

Lattice light sheet microscope

Optical microscopy has become one of the most powerful tools in medical research.

WEHI's Centre for Dynamic Imaging is advancing our understanding of how diseases develop, spread and respond to treatment.