Dr Paul Elliott - University of Oxford

Dr Paul Elliott - University of Oxford

Location: 
Davis Auditorium
Start Time: 
Tue, 29/11/2022 - 9:30am
End Time: 
Tue, 29/11/2022 - 10:30am

WEHI Special Seminar hosted by Professor David Komander

Dr Paul Elliott

Department of Biochemistry, University of Oxford

BRUCE Almighty

 

Davis Auditorium

Speaker will join via TEAMS

Including Q&A session

 

BRUCE (BIRC6), a giant E3 ubiquitin ligase is a member of the Inhibitor of Apoptosis Protein (IAP) family of proteins that regulates programmed cell death amongst other processes. Mechanistic details of what BRUCE looks like or how BRUCE achieves these functions have been lacking. I will present our insights into the first complete structure of BRUCE alone and in complex with SMAC, an antagonist of BRUCE and other IAPs. Importantly, I will also present the first thorough biochemical characterisation of BRUCE revealing how it restricts caspase activities and how sub-nanomolar binding of SMAC to BRUCE antagonises BRUCEs ability to restrict caspase activity, paving the way for future studies on this most almighty of proteins.



All welcome!