Dr Raymond Yip - ACRF Cancer Biology & Stem Cells division

Dr Raymond Yip - ACRF Cancer Biology & Stem Cells division

Location: 
Davis Auditorium
Start Time: 
Wed, 29/09/2021 - 1:00pm
End Time: 
Wed, 29/09/2021 - 2:00pm

WEHI Wednesday Seminar hosted by Professor Jane Visvader

 

Dr Raymond Yip

Research Officer, Breast Cancer Laboratory, ACRF Cancer Biology & Stem Cells division - Cancer Research & Treatments Theme



Imaging the bone microenvironment in breast cancer metastasis





Davis Auditorium

Online access via Slido and enter code #WEHIWEDNESDAY

Including Q&A session

 

Bone marrow is a common site for solid tumour metastasis. Accumulating evidence indicates that disseminated tumour cells colonise specialised niches to support their long-term propagation, but the precise location and mechanisms that support tumour-niche interactions are unknown. Using breast cancer as a model of solid tumour metastasis to the bone marrow, we performed large scale quantitative three-dimensional imaging to characterise temporal changes in the bone marrow microenvironment during disease progression. We illustrate how metastatic mammary tumour cells home to a distinct vascular district in the bone marrow and establish a tumour-supportive microenvironment through remodelling of the local vasculature. This work highlights the potential to target bone metastasis by intercepting tumour-niche interaction.

 

Dr Raymond Yip received his BSc (Hons) in Biochemistry and PhD in Developmental Biology from the University of Hong Kong. He joined the Breast Cancer Laboratory co-led by Prof. Jane Visvader and Prof. Geoff Lindeman at WEHI in 2017. During his postdoctoral training, he has translated his expertise in skeletal development to studying the role of the bone microenvironment in breast cancer metastasis.

 

All welcome!