Dr Stephin Vervoort - Epigenetics & Development division

Dr Stephin Vervoort - Epigenetics & Development division

Location: 
Davis Auditorium
Start Time: 
Mon, 04/07/2022 - 11:00am
End Time: 
Mon, 04/07/2022 - 12:15pm

Online Postgraduate Lecture – Cancer Seminar Series hosted by Associate Professor Gemma Kelly

Dr Stephin Vervoort

Laboratory Head, Epigenetics & Development division – Healthy Development & Ageing Theme, WEHI

Targeting epigenetic and transcriptional regulators for cancer therapy

 

Davis Auditorium

Online access via Slido and enter code #WEHIpostgrad

Including Q&A session

 

Dr Stephin Vervoort is laboratory head at the Walter and Eliza Hall Institute in the Epigenetics and Development division supported by a CSL Fellowship and starting from 2023 a Snow Fellowship. He completed his PhD at Utrecht University in The Netherlands where he worked on gene regulatory networks controlled by SOX transcription factors in cancer. After obtaining a Rubicon Fellowship from The Netherlands Organisation for Scientific Research he joined the laboratory of Professor Ricky Johnstone to work on the Therapeutic Targeting of Transcriptional Regulators. His work combines molecular biology and CRISPR/CAS9 genome engineering with next-generation sequencing-based genomics and functional genomics. Recent work on Epigenetic and Cyclin-Dependent Kinase (CDK) mediated control of RNA Polymerase II (RNAPII) driven transcription and the targeting thereof in the context of cancer was published in Cell (Vervoort et al. 2021), Science Advances (Fan et al. 2020) and Molecular Cell (Hogg et al. 2021).

In this presentation, he will discuss how gene expression is regulated under normal conditions, how dysregulation of this process drives cancer and how this creates a vulnerability that can be exploited therapeutically. 

All welcome!