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- Alistair Brown
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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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Art of Science 2022 finalists
Discover the beauty and wonder of Art of Science
What would you like to do?
- See the Still Image finalists
- Watch the Moving Image finalists
- Explore the full online exhibition
- Find out more about Art of Science
Still images
Against the grain by Kristy Shield-Artin and Suzan Sam
Blue cancer cells swirl around a yellow centre of secreted mucin in a tumour of the lung from a patient who has developed and survived three different cancers over more than a decade. The surrounding lung tissue in green shows reactive changes.
SECOND PLACE - STILL IMAGE CATEGORY
At ease by Bianca Capaldo
Breast tissue is seen in its resting state - luminal cells (purple) within an outer layer of myoepithelial cells (green). During breastfeeding, luminal cells grow and change to produce milk, which the myoepithelial cells propel along the ducts.
Chemokine chrysalis by Raymond Qin
Within a lymph node, small proteins called chemokines guide immune cells to distinct locations in response to foreign antigens, including cancer cells and infectious agents. The different colours in the image identify cells that produce different chemokines.
Crypto rain by Stefanie Bader
The sparkling ‘raindrops’ in this image are Cryptosporidium parasites, which cause a water-borne diarrhoeal illness responsible for 200,000 deaths per year around the world. Research is investigating different parasite components as potential targets for vaccines.
In bloom by Caleb Dawson
In response to hormones released during lactation, the ducts and lobules of breast tissue ‘bloom’ to form clusters of alveoli. These contain milk-producing cells encircled by tiny muscle-like cells, which contract to deliver milk to an infant.
FIRST PLACE - STILL IMAGE CATEGORY
Interweb of the mind by Melody Leong
This image shows two different types of nerve cells or neurons (depicted in red and blue) grown in the laboratory. Researchers are using these ‘cultured’ neurons to study how genetic mutations contribute to neurodevelopmental disorders associated with intellectual disability.
Keep an eye out by Melanie Dietrich
These 3D X-ray images show microscopic crystals formed by malaria parasite proteins interacting with ‘nanobodies’, small antibodies that can block parasite development and transmission.
Light in the dark by Kristy Shield-Artin and Suzan Sam
In this image of an ovarian tumour, different cell and tissue types have been stained with multiple fluorescent labels. Cyan specks identify immune cells whose role in tumour growth and response to treatment are under investigation.
Supernova by Stefanie Bader and Kathryn Davidson
This image shows organoids - miniature laboratory models of organs grown from patient biopsies - being used to test drugs targeting infections of the liver. The top ‘exploding’ liver organoid was treated with a drug that triggers the death of infected cells.
THIRD PLACE - STILL IMAGE CATEGORY
Through the looking glass by Sabrina Lewis
Each colour in this image represents a unique cancer cell type within a breast tumour. Researchers are studying how different cancer cells spread to distant organs to form metastases, which can have dire consequences for patient survival.
Toxo Actin’ Chill by Aurelie Dawson, Caleb Dawson and Cindy Evelyn
Toxoplasma gondii (‘Toxo’) parasites responsible for the infectious disease toxoplasmosis are shown ‘hiding’ inside a host cell to evade detection by the immune system. Toxo are pictured in yellow; the red filaments are the support ‘skeletons’ of the host cells.
Moving images
Watch our full Art of Science 2022 video playlist on YouTube.
Bad aberrations by Michael Mlodzianoski
Even high-tech modern microscopes are subject to aberrations that reduce the resolution and accuracy of images. The video shows the effects of different aberrations on the point spread function (PSF), a measure of image quality.
Red forest by Sabrina Lewis
This animation takes us on a 3D ride around and through the forest of blood vessels in a section of the lung. Research is examining how tumour cells in the lungs interact with blood vessels.
Popcorn Toxo by Aurelie Dawson and Caleb Dawson
The common and usually harmless parasite Toxoplasma gondii can cause the serious disease toxoplasmosis in infants born to infected mothers and in people with weakened immune systems. The video shows ‘Toxo’ parasites multiplying and flashing brightly as they burst out of infected cells.
THIRD PLACE - MOVING IMAGE CATEGORY
The tree of life by Kelin Zhao
This video shows a 3D view of the tree-like network of blood vessels in the thymus. Through this, precursors of immune cells called T-lymphocytes enter the gland to be selected and trained to recognise and target foreign antigens.
FIRST PLACE - MOVING IMAGE CATEGORY
Thymic coral reef by Kelin Zhao
The thymus is a vital immune gland where white blood cells called T-cells are ‘trained’ to respond to foreign antigens. The video shows a 3D reconstruction of a thymic lobe: the inner medulla has a large, branched central structure (purple) with small outer islets (various colours).
Transmission by Niall Geoghegan, Robyn McConville and Justin Boddey
Only male sexual stage Plasmodium parasites can transmit malaria from humans back to mosquitoes. Here they are seen dividing and bursting out of human red blood cells in the gut of a mosquito, ready to fertilise female parasites.
Web of lyse by George Ashdown and Niall Geoghegan
White blood cells called neutrophils are shown ‘weaponizing’ their own DNA - stained fluorescent orange - to trap and destroy pathogens by forming neutrophil extracellular traps (NETs).
What’s that, neuron? by Melody Leong and Yuqing Yang
A compilation of high-resolution microscope images shows successive cross-sections throughout a laboratory-grown nerve cell (neuron), which harbours a genetic mutation linked to neurodevelopmental disorders associated with intellectual disability.
SECOND PLACE - MOVING IMAGE CATEGORY
The (not so micro)glia by Matthias Mulazzani
Microglia - shown in yellow associated with blood vessels in blue - are immune cells resident in the brain. They support nerve cells, playing an important role in brain development and possibly in diseases like dementia, stroke and brain tumours.
More information
- Visit our 2022 Art of Science online exhibition
- Find out about the exhibition soundscape
- Explore our past Art of Science exhibitions