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- A complete cure for HBV
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- Activating SMCHD1 to treat FSHD
- Fut8 Sugar coating immuno oncology
- Improving vision outcomes in retinal detachment
- Intercepting inflammation with RIPK2 inhibitors
- Novel inhibitors for the treatment of lupus
- Novel malaria vaccine
- Novel therapy for drug-resistant cancers
- Precision epigenetics silencing SMCHD1 to treat Prader Willi Syndrome
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- Anne-Laure Puaux
- Associate Professor Aaron Jex
- Associate Professor Alyssa Barry
- Associate Professor Andrew Webb
- Associate Professor Anne Voss
- Associate Professor Chris Tonkin
- Associate Professor Daniel Gray
- Associate Professor Edwin Hawkins
- Associate Professor Emma Josefsson
- Associate Professor Ethan Goddard-Borger
- Associate Professor Grant Dewson
- Associate Professor Isabelle Lucet
- Associate Professor James Murphy
- Associate Professor Jeanne Tie
- Associate Professor Jeff Babon
- Associate Professor Joan Heath
- Associate Professor Justin Boddey
- Associate Professor Marco Herold Marco Herold
- Associate Professor Marie-Liesse Asselin-Labat
- Associate Professor Marnie Blewitt
- Associate Professor Matthew Ritchie
- Associate Professor Melissa Davis
- Associate Professor Oliver Sieber
- Associate Professor Peter Czabotar
- Associate Professor Rachel Wong
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- Associate Professor Seth Masters
- Associate Professor Sumitra Ananda
- Associate Professor Tim Thomas
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- Associate Professor Wei Shi
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- 6 cysteine proteins key mediators between malaria parasites and human host
- A balancing act of immunity: autoimmunity versus malignancies
- Activating https://www.wehi.edu.au/node/add/individual-student-research-page#Parkin to treat Parkinson’s disease
- Analysing single cell technologies to understand breast cancer
- Bioinformatics methods for detecting and making sense of somatic genomic rearrangements
- Characterising new regulators in inflammatory signalling pathways
- Computational melanoma genomics
- Control of human lymphocyte cell expansion in complex immune diseases
- Deciphering biophysical changes in red blood cell membrane during malaria parasite infection
- Deciphering the signalling functions of pseudokinases
- Deep profiling of blood cancers during targeted therapy
- Determining the mechanism of type I cytokine receptor triggering
- Differential expression analysis of RNA-seq using multivariate variance modelling
- Discovering new genetic causes of primary antibody deficiencies
- Discovery of novel drug combinations for the treatment of bowel cancer
- Drug targets and compounds that block growth of malaria parasites
- Effects of nutrition on immunity and infection in Asia and Africa
- Enabling deubiquitinase drug discovery
- Epigenetic drivers of immune cell function
- Epigenetic regulation of systemic iron homeostasis
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Fatal attraction: how apoptotic pore assembly is governed during mitochondrial cell death
- Genomic instability and the immune microenvironment in lung cancer
- How do T lymphocytes decide their fate?
- How the epigenetic regulator SMCHD1 works and how to target it to treat disease
- Human lung protective immunity to tuberculosis: host-environment systems biology
- Human monoclonal antibodies against malaria infection
- Identifying novel treatment options for ovarian carcinosarcoma
- Inflammasome activation in autoinflammatory disease
- Investigating mechanisms of cell death and survival using zebrafish
- Investigating microbial natural products with anti-protozoal activity
- Investigating the role of mutant p53 in cancer
- Investigating the role of platelets in motor neuron disease
- Mapping DNA repair networks in cancer
- Molecular mechanisms controlling embryonic lung progenitor cells
- Nanobodies against malaria
- Neutrophil heterogeneity in inflammation
- New approaches to treat cancer and inflammatory disease using the ubiquitin system
- Next generation CRISPR screens using iPSC
- Novel cell death and inflammatory modulators in lupus
- Programming T cells to defend against infections
- Restraining cytokine-receptor signalling in myeloproliferative neoplasms
- Screening for regulators of jumping genes
- Statistical analysis of genome-wide chromatin organisation using Hi-C
- Statistical analysis of trapped-ion-mobility time-of-flight mass spectrometry proteomics data
- Structure and function of E3 ubiquitin ligases
- Target identification of potent antimalarial agents
- The mitochondrial TOM complex in neurodegenerative disease
- The molecular mechanisms underlying Kir4.1 activity in gliomas
- The role of differential splicing in the genesis of breast cancer
- Uncovering the roles of long non-coding RNAs in human bowel cancer
- Understanding malaria infection dynamics
- Understanding the function of the E3 ligase Parkin in Parkinson’s disease
- Understanding the molecular basis of chromosome instability in gastric cancer
- Utilising pre-clinical models to discover novel therapies for tuberculosis
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Aaron Jex - Lab team
Researcher:
Lab team
Louise Baker, Institute/Melbourne Water Centenary Fellow for Water, Global Health and Innovation, BSc(Hons) Melbourne PhD Melbourne
Project: Development and application of molecular diagnostic tools for waterborne toxic, pathogenic and nuisance micro-organisms.
Key publication: Baker L, Sendall B, Gasser R, Menjivar T, Neilan B, Jex A. Rapid, multiplex-tandem PCR assay for automated detection and differentiation of toxigenic cyanobacterial blooms. Molecular and Cellular Probes. 2013. 27 (208-214). PMID 23850895.
Samantha Emery, Postdoctoral Fellow, BSc(Hons) Macquarie PhD Macquarie
Project: Quantitative proteomics and post-translational modification networks in the gastro-intestinal protist parasite Giardia duodenalis.
Key publication: Emery S, Mirzaei M, Vuong D, Pascovici D, Chick JM, Lacey E, Haynes PA. Induction of virulence factors in Giardia duodenalis independent of host attachment. Sci Rep 2016 6 20765. PMID: 26867958.
Hayley Joseph, Postdoctoral Fellow, BMedLabSc(Hons) James Cook PhD (Cum Laude) James Cook
Projects: i) Chemosensation in Ascaris infection, ii) Development of diagnostic tools for water-borne and water-associated infections, iii) Development of rapid diagnostics for Burkholderia pseudomallei
Key publication: Haparai L, Plichart C, Naseri T, Silva U, Tesimale L, Pemita P, Bossin H, Burkot T, Ritchie S, Graves P, Melrose W, Joseph H. Evaluation of traps and lures for mosquito vectors and xenomonitoring of Wuchereria bancrofti infection in a high prevalence Samoan village. Parasites and Vectors. 2015. 8(1): 287. DOI: 10.1186/s13071-015-0886-2. PMID: 26016830
Balu Balan, PhD Student, BSc Amrita MSc Amrita
Project: Functional and computational characterisation of Post Transcriptional Regulation in the early diverging eukaryotic protist parasite Giardia duodenalis.
Key Publication: Beri D, Balan B, Chaubey S, Subramaniam S, Surendra B, Tatu U. A disrupted transsulphuration pathway results in accumulation of redox metabolites and induction of gametocytogenesis in malaria. Scientific Reports. 2017 (40213). PMID: 28091526
Nijoy John, PhD Student, Dip Mgmt Adelaide BSc Bangalore MSc Bangalore MSc Flinders
Project: Molecular tools to detect toxic, taste and odour-producing cyanobacteria in various water resources.
Key publication: John N, Koehler AV, Ansell BRE, Baker L, Crosbie ND, Jex AR. An improved method for PCR-based detection and routine monitoring of geosmin-producing cyanobacterial blooms. Water Research. 2018 136 (34-40). PMID: 29494895
Jeffrey Smith, PhD Student, BA BSc(Hons), Grad.DipEd.
Project: Novel methods for global surveillance of RNA-binding proteins and their RNA binding partners.
Key publication: Pizzolla A, Nguyen T, Smith J, Brooks A, Kedzieska K, Heath W, Reading P, Wakim L. Resident memory CD8+ T cells in the upper respiratory tract prevent pulmonary influenza virus infection. Science Immunology 2017. PMID: 28783656
Katharina Stracke, PhD Student, BSc Würzburg MSc Aachen
Project: Impact of soil-transmitted helminth infections on pre-school children from Thailand.
Swapnil Tichkule, PhD Student, BTech Dehradun MTech Allahabad
Project: Population genomics study of Cryptosporidium species from whole genome sequences
Key publication: Kundu N, Tichkule S, Pandit SB, Chattopadhyay K. Disulphide bond restrains C-terminal region of thermostable direct hemolysin during folding to promote oligomerization. Biochemical Journal. 2017 474(2):317-331. PMID: 27784764
Rikvin Singh Rekhi, Honours student, BSc Melbourne
Super Content:
On World Water Day, Melbourne Water and the Walter and Eliza Hall Institute announced a joint research fellowship designed to improve the identification and control of water-borne illness.
Dr Samantha Emery has won a two-year grant from The Jack Brockhoff Foundation to support her studies in the parasite, Giardia duodenalis.
The Institute’s annual Art of Science exhibition has opened, with stunning images and videos captured by our researchers who are tackling some of the biggest challenges facing global health.