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- 6 cysteine proteins key mediators between malaria parasites and human host
- A balancing act of immunity: autoimmunity versus malignancies
- Activating https://www.wehi.edu.au/node/add/individual-student-research-page#Parkin to treat Parkinson’s disease
- Analysing single cell technologies to understand breast cancer
- Bioinformatics methods for detecting and making sense of somatic genomic rearrangements
- Characterising new regulators in inflammatory signalling pathways
- Computational melanoma genomics
- Control of human lymphocyte cell expansion in complex immune diseases
- Deciphering biophysical changes in red blood cell membrane during malaria parasite infection
- Deciphering the signalling functions of pseudokinases
- Deep profiling of blood cancers during targeted therapy
- Determining the mechanism of type I cytokine receptor triggering
- Differential expression analysis of RNA-seq using multivariate variance modelling
- Discovering new genetic causes of primary antibody deficiencies
- Discovery of novel drug combinations for the treatment of bowel cancer
- Drug targets and compounds that block growth of malaria parasites
- Effects of nutrition on immunity and infection in Asia and Africa
- Enabling deubiquitinase drug discovery
- Epigenetic drivers of immune cell function
- Epigenetic regulation of systemic iron homeostasis
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Fatal attraction: how apoptotic pore assembly is governed during mitochondrial cell death
- Genomic instability and the immune microenvironment in lung cancer
- How do T lymphocytes decide their fate?
- How the epigenetic regulator SMCHD1 works and how to target it to treat disease
- Human lung protective immunity to tuberculosis: host-environment systems biology
- Human monoclonal antibodies against malaria infection
- Identifying novel treatment options for ovarian carcinosarcoma
- Inflammasome activation in autoinflammatory disease
- Investigating mechanisms of cell death and survival using zebrafish
- Investigating microbial natural products with anti-protozoal activity
- Investigating the role of mutant p53 in cancer
- Investigating the role of platelets in motor neuron disease
- Mapping DNA repair networks in cancer
- Molecular mechanisms controlling embryonic lung progenitor cells
- Nanobodies against malaria
- Neutrophil heterogeneity in inflammation
- New approaches to treat cancer and inflammatory disease using the ubiquitin system
- Next generation CRISPR screens using iPSC
- Novel cell death and inflammatory modulators in lupus
- Programming T cells to defend against infections
- Restraining cytokine-receptor signalling in myeloproliferative neoplasms
- Screening for regulators of jumping genes
- Statistical analysis of genome-wide chromatin organisation using Hi-C
- Statistical analysis of trapped-ion-mobility time-of-flight mass spectrometry proteomics data
- Structure and function of E3 ubiquitin ligases
- Target identification of potent antimalarial agents
- The mitochondrial TOM complex in neurodegenerative disease
- The molecular mechanisms underlying Kir4.1 activity in gliomas
- The role of differential splicing in the genesis of breast cancer
- Uncovering the roles of long non-coding RNAs in human bowel cancer
- Understanding malaria infection dynamics
- Understanding the function of the E3 ligase Parkin in Parkinson’s disease
- Understanding the molecular basis of chromosome instability in gastric cancer
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Andreas Strasser - Lab team
Researcher:
All students and postdocs in my group have clearly demarcated projects. This helps maximise the areas of research that we can tackle. When work within an area needs to be accelerated, help is provided by other members from the lab, particularly research assistants.
We collaborate closely with the Gray and Herold laboratories, both of which are led by former postdocs from my lab, as well as with all other laboratories within the Molecular Genetics of Cancer division. My lab also has close collaborations with many laboratories from other divisions at the Institute, and many laboratories elsewhere in Australia and overseas.
Team
Lorraine O’Reilly, Senior Scientist, BSc Glasgow PhD London
Project: Investigating the role of NF-kB1 as a tumour suppressor in gastric cancer
Project: The use of monoclonal antibodies to isolate novel proteins involved in cellular life or death decisions
Project: Testing the potential of the NF-kB family member c-Rel as a therapeutic target in multiple common autoimmune diseases
Key publication: O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A. Loss of NF-kB1 causes gastric cancer with aberrant inflammation and expression of immune checkpoint regulators in a STAT-1-dependent manner. Immunity. 2018 Mar 20;48(3):570-583.e8. PMID: 29562203
Gemma Kelly, Senior Postdoctoral Fellow, BSc (Hons) Durham PhD Birmingham
Project: Investigating the role of mutant p53 and MCL-1 in the sustained growth of MYC driven lymphomas and strategies for targeted therapy
Project: Investigating the function of the Epstein-Barr virus-encoded viral BCL-2 homologue, BHRF1
Key publication: Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DC, Bouillet P, Rowe M, Rickinson AB, Herold MJ, Strasser A. Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53. Genes Dev. 2014 Jan 1;28(1):58-70. PMID: 24395247
Kerstin Brinkmann, Postdoctoral Fellow, BBiolSc(Hons) Cologne PhD Cologne
Project: The role of MCL-1 in protecting haematopoietic stem and progenitor cells from cancer therapeutics
Project: The molecular control of MCL-1 expression
Key publication: Brinkmann K, Grabow S, Hyland CD, Teh CE, Alexander WS, Herold MJ, Strasser A. The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice. Cell Death Differ. 2017 Dec;24(12):2032-2043. PMID: 28800129
Sarah Diepstraten, Postdoctoral Fellow, BSc(Hons) LaTrobe PhD LaTrobe
Project: Exploring the role of the pro-survival proteins Bcl-w and BFL1 in human cancers
Project: MCL-1 inhibitors as a targeted therapy for MYC-driven lymphomas.
Ana Janic, Postdoctoral Fellow, BSc Belgrade PhD Barcelona
Project: Identification of the critical p53 tumour suppression mechanisms by using in vivo shRNA library screening
Key publication: Janic A, Valente LJ, Wakefield MJ, Di Stefano L, Milla L, Wilcox S, Yang H, Tai L, Vandenberg CJ, Kueh AJ, Mizutani S, Brennan MS, Schenk RL, Lindqvist LM, Papenfuss AT, O’Connor L, Strasser A, Herold MJ. Sensitised in vivo shRNA screens identify effectors of p53-mediated tumour suppression and reveal a critical role of DNA repair. Nature Medicine. 2018 (in press).
Francine Ke, Postdoctoral Fellow, BSc (Hons) PhD Melbourne
Project: Understanding the role of cell death pathways in embryonic development
Project: Pharmacological inhibition of MCL-1 and BCL-XL to treat human medulloblastoma
Key publication: Ke F, Vanyai H, Cowan A, Whitehead L, Delbridge AR, Grabow S, Czabotar P, Voss AK, Strasser A. Rare instances of embryogenesis and adult life in the absence of the intrinsic apoptosis effectors BAX, BAK and BOK. Cell. 2018 (in press)
Shinsuke Mizutani, Postdoctoral Fellow, MD, PhD Kyoto
Project: Whole genome CRISPR screen to identify novel mechanisms of tumour suppression
Key publication: Mizutani S, Yoshida T, Zhao X, Nimer SD, Taniwaki M and Okuda T: Loss of Runx1/AML1 arginine-methylation impairs peripheral T cell homeostasis. Br J Haematol. 2015 Sep;170(6):859-73. PMID: 26010396
Melanie Heinlein, PhD Student, BSc MSc Albert-Ludwigs Freiburg
Project: Novel regulators of immunological tolerance
Key publication: Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Häcker G. The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. EMBO Rep. 2016 May;17(5):724-38.PMID: 27013495
Lizzie Lieschke, PhD Student, BSc(Hons) Melbourne
Project: Investigating the contributions of cell death, cell cycle arrest and cell senescence to p53 mediated tumor suppression
Jun Ting Low, PhD Student, BBiomedSc (Hons) Melbourne
Project: Understanding the Role of NF-kB1 in Gastric Cancer
Key publication: Low JT, Hughes P, Lin A, Siebenlist U, Jain R, Yaprianto K, Gray DH, Gerondakis S, Strasser A, O'Reilly LA. Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice. Immunol Cell Biol. 2016 Jan;94(1):66-78. PMID: 26084385
Zilu Wang, PhD Student, MD, MSc, Nanjing Medical University
Project: Identification of the mechanisms of APR-246 induced killing of tumour cells.
Catherine Chang, Research Assistant, BBiomedSc Melbourne
Super Content:
Researchers have genetically engineered a laboratory model for testing the effectiveness of new anti-cancer drugs called MCL-1 inhibitors.
Institute researchers have led a study suggesting that abnormalities in cell death (apoptosis) could be linked to common birth defects including spina bifida.
Support from Cancer Council NSW is enabling our researchers to develop ways to better detect the early stages of stomach cancer.
Cell death researcher Associate Professor James Murphy and cancer researcher Dr Gemma Kelly are joint winners of the 2017 Burnet Prize, the Institute's top science prize.