Publications

1. Gearing DP, Gough NM, King JA, HILTON DJ, Nicola NA, Simpson RJ, Nice EC, Kelso A, Metcalf D. Molecular cloning and expression of cDNA encoding a murine myeloid leukemia-inhibitory factor (LIF). EMBO J 6: 3995-4002, 1987. PMID: 3127201
2. HILTON DJ, Nicola NA, Metcalf D. Purification of a murine leukemia inhibitory factor from Krebs Ascites cells. Anal Biochem 173: 359-67, 1988. PMID: 3142300
3. HILTON DJ, Nicola NA, Metcalf D. Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells. Proc Natl Acad Sci USA 85: 5971-5, 1988. PMID: 3137563
4. Williams RL, HILTON DJ, Pease S, Willson TA, Stewart CL, Gearing DP, Wagner EF, Metcalf D, Nicola NA, Gough NM. Myeloid leukemia inhibitory factor (LIF) maintains the developmental potential of embryonic stem cells. Nature 336: 684-7, 1988. PMID: 3143916
5. HILTON DJ. LIF: Lots of interesting functions. Trends Biochem Sci 17: 72-6, 1992. PMID:1566332
6. HILTON DJ, Hilton AA, Raicevic A, Rakar S, Harrison-Smith M, Gough NM, Begley CG, Metcalf D, Nicola NA, Willson TA. Cloning of a murine IL-11 receptor alpha chain; requirement of gp130 for high affinity binding and signal transduction. EMBO J 13: 4765-75, 1994. PMID: 7957045
7. HILTON DJ, Watowich SS, Murray PJ, Lodish HF. Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor. Proc Natl Acad Sci USA 92: 190-4, 1995. PMID: 7816815
8. HILTON DJ, Zhang J-G, Metcalf D, Alexander W, Nicola NA, Willson TA. Cloning and characterization of a binding subunit of the interleukin-13 receptor that is also a component of the interleukin-4 receptor. Proc Natl Acad Sci USA 93: 497-501, 1996. PMID: 8552669
9. Starr R, Willson TA, Viney EM, Murray LJL, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, HILTON DJ. A family of cytokine-inducible inhibitors of signalling. Nature 387: 917-21, 1997. PMID: 9202125
10. HILTON DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci USA 95: 114-9, 1998. PMID: 9419338
11. Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TWH, Nicola NA, Hertzog PJ, Metcalf D, HILTON DJ. SOCS1 is a critical inhibitor of interferon gamma signalling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98: 597-608, 1999. PMID: 10490099
12. Zhang J-G, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson, RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SBH, Alexander WS, Metcalf D, HILTON DJ, Nicola NA, Baca M. The conserved SOCS box motif in suppressors of cytokine signalling binds to elongins B and C and may couple proteins to proteasomal degradation. Proc Natl Acad Sci USA 96: 2071-6, 1999. PMID: 10051596
13. Metcalf D, Greenhalgh CJ, Viney E, Willson T, Nicola NA, HILTON DJ, Alexander WS. Gigantism in mice lacking suppressor of cytokine signaling-2. Nature 405: 1069-73, 2000. PMID: 10890450
14. Roberts AW, Robb L, Rakar S, Hartley L, Cluse L, Nicola NA, Metcalf D, HILTON DJ, Alexander WS. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci USA 98: 9324-9, 2001. PMID: 11481489
15. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HME, HILTON DJ. The SOCS box: a tale of destruction and degradation. Trends Biochem Sci 27: 235-41, 2002. PMID: 12076535
16. Carpinelli MR*, HILTON DJ*, Metcalf D, Antonchuk JL, Hyland CD, Mifsud SL, Di Rago L, Hilton AA, Willson TA, Roberts AW, Ramsay RG, Nicola NA, Alexander WS. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci USA 101: 6553-8, 2004 (* joint first authors). PMID: 15071178
17. Alexander WS and HILTON DJ. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Ann Rev Immunol 22: 503-29, 2004. PMID: 15032587
18. Loughran SJ, Kruse EA, Hacking DF, de Graaf CA, Hyland CD, Willson TA, Henley KJ, Ellis S, Voss AK, Metcalf D, HILTON DJ*, Alexander WS*, Kile BT.* The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol 9: 810-819, 2008 (* joint senior authors). PMID: 18500345
19. De Graaf CA, Kauppi M, Baldwin T, Hyland C, Metcalf D, Willson TA, Carpinelli MR, Smyth GK, Alexander WS, Pimanda JE, Hilton DJ. Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci USA 107: 21689-94, 2010. PMID: 21115812
20. Taoudi S, Bee T, Hilton A, Kenzevic K, Scott J, Willson TA, Collin C, Thomas T, Voss AK, Kile BT, Alexander WS, Pimanda JE, Hilton DJ. ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev 25: 251-62, 2011. PMID: 21245161
21. Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O’Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker BA. NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity 37: 1009-23, 2012. PMID: 23219391
22. Ng AP, Kauppi M, Metcalf D, Hyland CD, Josefsson EC, Lebois M, Zhang JG, Baldwin TM, Di Rago L, Hilton DJ, Alexander WS. Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation. Proc Natl Acad Sci USA 111: 5884-9, 2014. PMID: 24711413
23. Potts KS, Sargeant TJ, Markham JF, Shi W, Biben C, Josefsson EC, Whitehead LW, Rogers KL, Liakhovitskaia A, Smyth GK, Kile BT, Medvinsky A, Alexander WS, Hilton DJ, Taoudi S. A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Blood 2014 Jul 25. pii: blood-2014-02-559468. PMID: 25079356
24. de Graaf CA, Choi J, Baldwin TM, Bolden JE, Fairfax KA, Robinson AJ, Biben , Morgan C, Ramsay K, Ng AP, Kauppi M, Kruse EA, Sargeant TJ, Seidenman N, D'Amico A, D'Ombrain MC, Lucas EC, Koernig S, Baz Morelli A, Wilson MJ, Dower SK, Williams B, Heazlewood SY, Hu Y, Nilsson SK, Wu L, Smyth GK, Alexander WS, Hilton DJ. Haemopedia: an expression atlas of murine hematopoietic cells. Stem Cell Reports. 2016 Sep 13;7(3):571-582. PMID: 27499199
25. Lemieux S, Sargeant T, Laperrière D, Ismail H, Boucher G, Rozendaal M, Lavallée VP, Ashton-Beaucage D, Wilhelm B, Hébert J, Hilton DJ, Mader S, Sauvageau G. MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets. Nucleic Acids Res. 2017 Jul 27;45(13):e122. PMID: 28472340