Selected publications

1. Hyslop SR, Josefsson EC. Undercover Agents: Targeting Tumours with Modified Platelets. Trends Cancer. 2017 Mar;3(3):235-246. doi:10.1016/j.trecan.2017.01.006. PMID: 28718434
2. Au AE, Josefsson EC. Regulation of platelet membrane protein shedding in health and disease. Platelets. 2017 Jun;28(4):342-353. doi:10.1080/09537104.2016.1203401. PMID: 27494300
3. Lebois M, Dowling MR, Gangatirkar P, Hodgkin PD, Kile BT, Alexander WS, Josefsson EC. Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling. J Thromb Haemost. 2016 Sep;14(9):1882-7. doi: 10.1111/jth.13397. Epub 2016 Aug 11. PMID: 27344013
4. Lebois M, Josefsson EC. Regulation of platelet lifespan by apoptosis. Platelets. 2016 Sep;27(6):497-504. doi: 10.3109/09537104.2016.1161739. PMID: 27100842
5. Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, Kile BT, Josefsson EC. BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death Disease. 2015 Apr 16;6:e1721. doi: 10.1038/cddis.2015.97. PMID: 25880088
6. Josefsson, EC, Burnett, DL, Lebois, M, Debrincat, MA, White, MJ, Henley, KJ, Lane, RM, Moujalled, D, Preston, SP, O'Reilly, LA, Pellegrini, M, Metcalf, D, Strasser, A & Kile, BT Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nature Communications. 2014.5, 3455 doi: 10.1038/ncomms4455 PMID: 24632563
7. *Debrincat MA, *Josefsson EC, *James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT. Mcl-1 and Bcl-xL co-ordinately regulate megakaryocyte survival. Blood. 2012 119(24):5850-8 PMID: 22374700. *Joint First Authors
8. *Jansen AJ, *Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. Blood. 2012 119(5):1263-73. PMID: 22101895. *Joint First Authors
9. Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. The Journal of Experimental Medicine. 2011 208(10):2017-31. PMID: 21911424
10. Schoenwaelder SM, Yuan Y, Josefsson EC, White MJ, Yao Y, Mason KD, O'Reilly LA, Henley KJ, Ono A, Hsiao S, Willcox A, Roberts AW, Huang DC, Salem HH, Kile BT, Jackson SP. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood. 2009 114(3):663-6. PMID: 19387006.