Selected publications

1. Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC. Intrinsic apoptosis circumvents the functional decline of circulating platelets, but does not cause the storage lesion. Blood. 2018 May 21. pii: blood-2017-11-816355. doi:10.1182/blood-2017-11-816355. [Epub ahead of print] PMID: 29784641
2. Au AE, Lebois M, Sim SA, Cannon P, Corbin J, Gangatirkar P, Hyland CD, Moujalled D, Rutgersson A, Yassinson F, Kile BT, Mason KD, Ng AP, Alexander WS, Josefsson EC. Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling. Sci Rep. 2017 Nov 2;7(1):14953. doi: 10.1038/s41598-017-15023-2. PMID: 29097774
3. Yuan Y, Alwis I, Wu MCL, Kaplan Z, Ashworth K, Bark D Jr, Pham A, Mcfadyen J, Schoenwaelder SM, Josefsson EC, Kile BT, Jackson SP. Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Sci Transl Med. 2017 Sep 27;9(409). pii: eaam5861. doi: 10.1126/scitranslmed.aam5861. PMID: 28954929
4. Hyslop SR, Josefsson EC. Undercover Agents: Targeting Tumours with Modified Platelets. Trends Cancer. 2017 Mar;3(3):235-246. doi:10.1016/j.trecan.2017.01.006. PMID: 28718434
5. Lebois M, Dowling MR, Gangatirkar P, Hodgkin PD, Kile BT, Alexander WS, Josefsson EC. Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling. J Thromb Haemost. 2016 Sep;14(9):1882-7. doi: 10.1111/jth.13397. Epub 2016 Aug 11. PMID: 27344013
6. Lebois M, Josefsson EC. Regulation of platelet lifespan by apoptosis. Platelets. 2016 Sep;27(6):497-504. doi: 10.3109/09537104.2016.1161739. PMID: 27100842
7. Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, Kile BT, Josefsson EC. BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death Disease. 2015 Apr 16;6:e1721. doi: 10.1038/cddis.2015.97. PMID: 25880088
8. Josefsson, EC, Burnett, DL, Lebois, M, Debrincat, MA, White, MJ, Henley, KJ, Lane, RM, Moujalled, D, Preston, SP, O'Reilly, LA, Pellegrini, M, Metcalf, D, Strasser, A & Kile, BT Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nature Communications. 2014.5, 3455 doi: 10.1038/ncomms4455 PMID: 24632563
9. *Debrincat MA, *Josefsson EC, *James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT. Mcl-1 and Bcl-xL co-ordinately regulate megakaryocyte survival. Blood. 2012 119(24):5850-8 PMID: 22374700. *Joint First Authors
10. Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. The Journal of Experimental Medicine. 2011 208(10):2017-31. PMID: 21911424