Selected publications

1. Murphy JM*, Czabotar PE*, Hildebrand JM*, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RCJ, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity. 2013 19 September 2013;39(3):443-53. PMID: 24012422
2. Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM*, Silke J*. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. PMID: 25288762
3. Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J*, Murphy JM* (2016) Evolutionary divergence of the necroptosis effector MLKL Cell Death Differ 2016 Jul;23(7):1185-97. PMID: 26868910
4. Murphy JM, Lucet IS, Hildebrand JM, Tanzer MC, Young SN, Sharma P, Lessene G, Alexander WS, Babon JJ, Silke J, Czabotar PE. Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL. Biochem J. 2014 Feb 1;457(3):369-77. PMID: 24219132
5. Jacobsen AV, Lowes KN, Tanzer MC, Lucet IS, Hildebrand JM, Petrie EJ, van Delft MF, Liu Z, Conos SA, Zhang JG, Huang DCS, Silke J, Lessene G*, Murphy JM* (2016) HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death Cell Death Dis 7:e2051  PMID: 26775703
6. Babon JJ*, Kershaw NJ*, Murphy JM*, Varghese LN, Laktyushin A, Young SN, Lucet IS, Norton RS, Nicola NA. Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity. 2012 Feb 24;36(2):239-50. PMID: 22342841
7. Murphy JM, Korzhnev DM, Ceccarelli DF, Briant DJ, Zarrine-Afsar A, Sicheri F, Kay LE, Pawson T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14336-41. PMID: 17726107
8. Murphy JM*, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS*. A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. Biochem J. 2014 Jan 15;457(2):323-34. PMID: 24107129.
9. Murphy JM, Nakatani Y, Jamieson SA, Dai W, Lucet IS, Mace PD (2015) Molecular mechanism of the CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase. Structure 23(11):2111-21 PMID: 26455797
10. Chen K, Hu J, Moore DL, Liu R, Kessans SA, Lucet IS, Keniry A, Leong HS, Parish CL, Hilton DJ, Lemmers RJ, van der Maarel SM, Czabotar PE, Dobson RC, Ritchie ME, Kay GF*, Murphy JM*, Blewitt ME* (2015) Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation. PNAS 112(27):E3535-44 PMID: 26091879

* denotes equal contributions

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