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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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Publications
Researcher:
Selected Publications
- Mweempwa, A., Rosenthal, M, A., Dimou, J., Drummond, K, J., & WHITTLE, J, R. (2021) Perioperative clinical trials for glioma: raising the bar. Journal of Clinical Neuroscience. Senior and corresponding author PMID: 34119258
- WHITTLE, J, R., Vaillant, F., Surgeon, E., Policheni, A., Giner, G., Capaldo, B, D., Chen, H., Liu, H, K., Dekkers, J, F., Sachs, N., Clevers, H., Fellowes, A., Green, T., Xu, H., Fox, S, B., Herold, M, J., Smyth, G, K., Gray, D, H, D., Visvader, J, E., and Lindeman, G, J (2020). Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer. Clinical Cancer Research. doi: 10.1158/1078-0432.CCR-19-1872. PMID: 32245900
- Dekkers, J, F.,* WHITTLE, J, R.,* Vaillant, F., Chen, H., Dawson, C., Liu, K., Geurts, M, H., Herold, M, J., Clevers, H., Lindeman, G, J., and Visvader J, E. (2020) Modelling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids. Journal of the National Cancer Institute, 112(5), 540 – 544. doi: 10.1093/jnci/djz196. * equal contribution. PMID: 31589320
- Lok, S, W.,* WHITTLE, J, R.,* Vaillant, F., Teh, C., Lo, L, L., Policheni, A, N., Bergin, A, R, T., Desai, J., Ftouni, S., Gandolfo, L, C., Liew, D., Liu, H, K., Mann, G, B., Moodie, K., Murugasu, A., Pal, B., Roberts, A, W., Rosenthal, M, A., Shacleton, K., Silva, M, J., Siow, Z, R., Smyth, G, K., Taylor, L., Travers, A., Yeo, B., Yeung, M, M., Bujak, A, Z., Dawson, S, J., Gray, D, H, D., Visvader, J, E., and Lindeman, G, J. (2019) A phase Ib dose-escalation and expansion study of the BCL2 inhibitor venetoclax combined with tamoxifen in ER and BCL2–positive metastatic breast cancer. Cancer Discovery, 9(3), 354 – 369. (doi: 10.1158/2159-8290.CD-18-1151). (IF 26.3370; Citations 53). * equal contribution. PMID: 30518523
- Merino, D.*, WHITTLE, J, R.,* Vaillant, F.,* Serrano, A., Gong, J., Giner, G., Maragno, A, L., Scheider, E., Pal, B., Li, X., Dewson, G., Grasel, J., Liu, K., Lalaoui, N., Segal, D., Herold, M., Huang, D., Smyth, G., Geneste, O., Lessene, G., Visvader, J, E., and Lindeman, G, J. (2017) Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple- negative and HER2-amplified breast cancer. Science Translational Medicine, 9(401). (doi: 10.1126/scitranslmed.aam7049). * equal contribution. PMID: 28768804
- WHITTLE, J, R. Lickliter, J, D., Gan, H, K., Scott, A, M., Simes, J... and Rosenthal, M. First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma. (2015), Journal of Clinical Neuroscience, 22(12): 1889 – 94. (10.1016/j.jocn.2015.06.005). PMID: 26279503