Selected publications

1. Kim EJY, Anko ML, Flensberg C, Majewski IJ, Geng FS, Firas J, Huang DCS, van Delft MF, Heath JK. BAK/BAX-mediated apoptosis is a Myc-induced roadblock to reprogramming. Stem Cell Reports. 2018 Jan 17. pii: S2213-6711(17)30567-2. doi: 10.1016/j.stemcr.2017.12.019. [Epub ahead of print] PMID: 29358089
2. Keightley MC, Carradice DP, Layton JE, Pase L, Bertrand JY, Wittig JG, Dakic A, Badrock AP, Cole NJ, Traver D, Nutt SL, McCoey J, Buckle AM, Heath JK, Lieschke GJ. The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger. Nat Commun. 2017 Apr 6;8:14911. doi: 10.1038/ncomms14911. PMID: 28382966
3. Lobert VH, Mouradov D, Heath JK. Focusing the spotlight on the zebrafish intestine to illuminate mechanisms of colorectal cancer. Adv Exp Med Biol. 2016;916:411-37. doi: 10.1007/978-3-319-30654-4_18. Review. PMID: 27165364
4. Keightley MC, Markmiller S, Love CG, Rasko JE, Lieschke GJ, Heath JK. Experimental approaches to studying the nature and impact of splicing variation in zebrafish. Methods Cell Biol. 2016;135:259-88. d10.1016/bs.mcb.2016.02.006. Epub 2016 Mar 9. PMID: 27443930
5. Williams BB, Tebbutt NC, Buchert M, Putoczki TL, Doggett K, Bao S, Johnstone CN, Masson F, Hollande F, Burgess AW, Scott AM, Ernst M, Heath JK. Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease. Dis Model Mech. 2015 Aug 1;8(8):805-15. PMID: 26035389
6. Markmiller S, Cloonan N, Lardelli RM, Doggett K, Keightley MC, Boglev Y, Trotter AJ, Ng AY, Wilkins SJ, Verkade H, Ober EA, Field HA, Grimmond SM, Lieschke GJ, Stainier DY, Heath JK. Minor class splicing shapes the zebrafish transcriptome during development. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3062-7. PMID: 24516132
7. Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen P, Preaudet A, Farid R, Edwards K, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BJ, Nash A, Greten FR, McKenzie BS, Ernst M. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell 2013 Aug 12;24(2):257-71. PMID: 23948300
8. Boglev Y, Badrock AP, Trotter AJ, Du Q, Richardson EJ, Parslow AC, Markmiller SJ, Hall NE, de Jong-Curtain TA, Ng AY, Verkade H, Ober EA, Field HA, Shin D, Shin CH, Hannan KM, Hannan RD, Pearson RB, Kim SH, Ess KC, Lieschke GJ, Stainier DY, Heath JK. Autophagy induction is a tor- and tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genet. 2013 Feb;9(2):e1003279. PMID: 23408911
9. Keightley MC, Crowhurst MO, Layton JE, Beilharz T, Markmiller S, Varma S, Hogan BM, de Jong-Curtain TA, Heath JK and Lieschke GJ. In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation. FEBS Lett. 2013 Jul 11;587(14):2150-7. PMID: 23714367
10. Johnston AP, Kamphuis MM, Such GK, Scott AM, Nice EC, Heath JK, Caruso F. Targeting cancer cells: controlling the binding and internalization of antibody-functionalized capsules. ACS Nano. 2012 Aug 28;6(8):6667-74. PMID: 22872125

Further publications