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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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Leanne Robinson-Projects
Researcher:
Relapsing P. vivax infections in Papua New Guinean children
Plasmodium vivax has the ability to cause relapsing infections from long-lasting liver stages called hypnozoites. By studying the effect of removing long lasting liver-stages with primaquine treatment on the subsequent risk of P. vivax infection and illness, we have demonstrated that relapses cause around 80 per cent of P. vivax infections in PNG children and are important in sustaining transmission.
Data from these cohort studies is also being used to develop mathematical models of P. vivax relapses to predict the effectiveness of various intervention strategies against P. vivax and study within host, clonal dynamics.
Impact of malaria control on the epidemiology and transmission of P. falciparum and P. vivax malaria in Papua New Guinea
The intensification of the PNG malaria control program over the past 10 years is significantly reducing the burden of malaria and changing the complex relationships between parasites, human hosts and mosquito vectors.
Through a series of repeated community cross-sectional surveys, longitudinal child cohort studies, entomological surveys and hospital-based surveillance in two endemic areas of the country, we are using sensitive molecular diagnostics to monitor the impact of these changes on the age-specific burden of malaria, the natural acquisition of immunity, behavior of vectors and risk factors for infection and transmission, so as to be able to inform ongoing and future control efforts.
The dynamics of malaria transmission stages in host and vector
This study aims to determine the risk factors for Plasmodium spp. gametocyte carriage and study the temporal associations between the presence and complexity of asexual and sexual Plasmodium spp. infections. In parallel, the study will investigate the relationship between the presence and density of gametocyte in a blood samples and its infectivity to local vectors by conducting a series of standard mosquito membrane feeding assays.
Knowledge of the gametocyte carriers in a population, when gametocytes are most prevalent, and what are the determinants of infectivity to the mosquito vector, is essential for improving the implementation of current control tools and informing the development of novel interventions aimed at the interruption of local transmission.
Natural acquisition of immunity to P. falciparum and P. vivax in pregnancy, infancy and childhood
Our understanding of antibody and cellular immune responses that underpin the development of natural immunity to malaria is still evolving. Utilising samples collected during longitudinal cohort studies of pregnant women, infants and children in Madang and Maprik areas of PNG, we are investigating the dynamics of antibody and cellular immune responses, their acquisition, suppression, boosting and maintenance.
In addition, we are investigating trans-placental transfer of antibodies to infectious diseases and the role of pre-natal malaria exposure on immune responses and all-cause morbidity during infancy.