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- Analysis and reporting of whole genome sequencing data from malaria parasites
- Analysis of long read data from the minION, with application to malaria
- Analysis of short tandem repeat markers from whole genome sequencing
- Antibody longevity following Plasmodium vivax infections
- Antigenic diversity of malaria parasites: towards more effective malaria vaccines
- Biogenesis of eosinophil granules
- Biological sequence analysis and genomic variant discovery
- Biology of the unique intra-mitochondrial bacterium Midichloria mitochondrii
- Characterising regulatory T cells in coeliac disease
- Chemical probing to identify effectors of necroptotic cell death
- Computational systems biology of Wnt/cell adhesion signalling in colon cancer
- Controlling apoptotic cell death in cancer
- Deciphering mechanisms of thrombocytopenia (low platelet count) in blood cancers
- Defining molecular signatures of drug resistance and sensitivity
- Designing immunotherapy for brain cancer
- Developing non-invasive methods to monitor kidney transplant rejection
- Discovery and analysis of autoimmune regulators
- Discovery of novel drug combinations for the treatment of bowel cancer
- Drug targets and compounds that block growth of malaria parasites
- Dying to survive: mechanistic insights into human bowel cancer development
- Dynamic discovery of innate immunity through imaging and genomics
- Dysregulation of TNF expression in inflammatory diseases
- Effects of nutrition on immunity and infection in Asia and Africa
- Elucidation of long range methylation structure using nanopore sequencing
- Eosinophil activation
- Eosinophil death
- Eosinophil heterogeneity
- Eosinophil maturation
- Epigenetic regulation of systemic iron homeostasis
- Epigenetic regulation of the immune system
- Explosive cell death and human disease
- Export of malaria virulence proteins during liver infection
- Function of proteins involved in invasion of erythrocytes by malaria parasites
- Functional genomics to improve therapeutic options for rare cancers
- Giardia duodenalis phosphoproteome and protein kinase network
- Harnessing the immune system to target small cell lung cancer
- Home renovations: understanding how Toxoplasma redecorates its host cell
- How do malaria parasites traverse human cells and invade hepatocytes?
- How does the malaria parasite prevent the host liver cell from dying?
- Human monoclonal antibodies against malaria infection
- IL5 signalling in asthma
- Identification of genes critical for the control of chronic infections
- Identification of malaria parasite entry receptors
- Identifying new cell death and inflammatory pathways
- Identifying proteome signatures of high grade glioma for precision medicine
- Insight into the cytotoxic T cell immune synapse
- Investigating apoptosis control in tumour blood vessels
- Investigating brain abnormalities with single cell ‘omics
- Investigating mechanisms of cell death and survival using zebrafish
- Investigating the mechanics of platelet formation
- Investigating the molecular regulation of neovascular eye disease
- Let me in! How Toxoplasma invades human cells
- Long-read sequencing for transcriptome and epigenome analysis
- Machine learning analysis of mutagenesis datasets
- Macro-evolution in cancer
- Mapping human gene mutations affecting anti-malarial drug efficacy
- Mechanism and modulation of K+ channels and membrane transporters
- Mechanisms of disease relapse in acute lymphoblastic leukaemia
- Microbiome analysis using long read nanopore sequencing
- Molecular mechanism underpinning dendritic cell ontogeny and functions
- Molecular mechanisms of innate immune signalling
- Next-generation mucolytics to treat lung diseases
- No sex please, we’re inhibited: searching for drugs to prevent malaria transmission
- Novel biomarkers and mechanisms of antimalarial drug resistance
- Novel real-time, quantitative imaging approaches for studying malaria
- Novel regulators of JAK-STAT signalling in development and disease
- Novel tool for malaria surveillance and intervention
- Optimising serological markers of recent exposure to Plasmodium vivax
- Quantitation of human T cell responses in primary immunodeficiency
- Reconciling intracellular imaging and metastatic behaviour in cancer cells
- Reconstructing the immune response: from molecules to cells to systems
- Role of protein glycosylation in malaria virulence
- Statistical bioinformatic analyses of RNA-seq and ChIP-seq data
- Strategies mammalian cells use to survive without growth factors
- Structural and biochemical studies on Notch signal transduction
- Structural and functional analysis of malaria invasion
- Structural biology and binding studies of BCL-2 family proteins
- Structural studies of invasion processes during malaria infection
- Structural studies of the Plasmodium and Toxoplasma tight-junction complex
- Target identification of potent antimalarial agents
- The role of glycosylation in malaria vaccine design
- Towards a molecular description of plasma cell diversity
- Tracking the spread of malaria in the Asia Pacific region
- Transmembrane control of type I cytokine receptor activation
- Uncovering the roles of long non-coding RNAs in human bowel cancer
- Understanding resistance to apoptotic cell death
- Understanding the common through study of the rare
- Understanding the development of humoral immunity to malaria
- Unravelling cellular circuitry with single cell RNA-seq and CRISPR
- Unravelling the molecular architecture of killer T cells in disease
- Why is interleukin-11 elevated in acute myeloid leukaemia?
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Melissa Call-Projects
Researcher:
T cell receptor structure and function
The T cell antigen receptor (TCR) recognizes peptide fragments bound to major histocompatibility complex (MHC) proteins, activating T cells to kill target cells and/or secrete soluble factors. While the structural determinants of ligand discrimination are well studied, the mechanism by which receptor engagement outside the cell is sensed by signalling molecules inside the cell is still an open question. We are combining disulphide mapping and solution NMR techniques to determine how the eight-subunit receptor complex is arranged within the membrane and how transmembrane structure and dynamics relate to receptor activation.
Team member: Logesvaran Krshnan
DAP12-dependent NK cell receptor assembly and function
Natural killer (NK) cells are lymphocytes that eliminate cells exhibiting dysregulated MHC or otherwise altered cell-surface phenotypes, often due to viral infection or oncogenic transformation. A vast array of receptors governs the balance between NK cell cytotoxicity and quiescence, and many of the activating receptors depend on a homodimeric signalling module called DAP12 to supply cytosolic links to intracellular biochemical cascades. This project applies solution NMR and, more recently, lipidic cubic phase (LCP) crystallography techniques to examine the transmembrane structures adopted by DAP12 during assembly with “client” receptors.
Team member: Konstantin Knoblich
Regulation of cell-surface immune-regulatory proteins by MARCH-family e3 ubiquitin ligases
The levels of peptide:MHC complexes and other immunologically relevant proteins available at the cell surface can be modulated by regulatory proteins of the Membrane-Associated RING-CH (MARCH) family. MARCHs are integral membrane proteins with alpha-helical TM domains and cytosolic ubiquitin ligase domains. We use cellular biochemical and flow-cytometry based functional assays combined with solution NMR and lipidic cubic phase (LCP) crystallography techniques to study how MARCH proteins trap substrates through interactions with their TM domains. The major aim of this project is to identify what structural motifs govern substrate identification and thereby identify new substrates and molecular pathways that are MARCH-regulated.
Team members: Cyrus Tan and Raphael Trenker