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- Diseases
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- A new regulator of stemness to create dendritic cell factories for immunotherapy
- Advanced methods for genomic rearrangement detection
- Control of cytokine signaling by SOCS1
- Defining the protein modifications associated with respiratory disease
- Delineating the pathways driving cancer development and therapy resistance
- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
- Development and mechanism of action of novel antimalarials
- Development of a novel particle-based malaria vaccine
- Development of tau-specific therapeutic and diagnostic antibodies
- Discovering novel therapies for major human pathogens
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Epigenetic biomarkers of tuberculosis infection
- Essential role of glycobiology in malaria parasites
- Evolution of haematopoiesis in vertebrates
- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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- Renewed support for HIV eradication project
- Searching for solutions to muscular dystrophy
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- Taking a single cell focus with the DROP-seq
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Melissa Call-publications
Researcher:
Selected publications
- Bridgford JL, Lee SM, Lee CMM, Guglielmelli P, Rumi E, Pietra D, Wilcox S, Chhabra Y, Rubin AF, Cazzola M, Vannucchi AM, Brooks AJ, Call ME*, Call MJ*. Novel Drivers and Modifiers of MPL-dependent Oncogenic Transformation Identified by Deep Mutational Scanning. Blood. 2020 Jan 23;135(4):287-292. doi: 10.1182/blood.2019002561 PMID: 31697803
- Tan C, Byrne EFX, Ah-Cann C, Call MJ*, Call ME*. A serine the first transmembrane domain of the human E3 ubiquitin ligase MARCH9 is critical for down-regulation of its protein substrates. J Biol Chem. 2019 294(7):2470-2485. PMID: 30554144
- Park S, Krshnan L, Call MJ, Call ME*, Im W*. Structural conservation and effects of alterations in T cell receptor transmembrane interfaces. Biophys J. 2018 Mar 13;114(5):1030-1035 PMID: 29395047
- Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. 2018 Jan 5;359(6371):48-55. PMID: 29302006
- Blázquez-Moreno A, Park S, Im W, Call MJ, Call ME*, Reyburn HT*. Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5645-E5654 PMID: 28652325
- Trenker R, Call MJ*, Call ME*. Progress and prospects for structural studies of transmembrane interactions in single-spanning receptors. Curr Opin Struct Biol. 2016 Aug;39:115-123. PMID: 27423296
- Krshnan L, Park S, Im W, Call MJ*, Call ME*. A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6649-E6658 PMID: 27791034
- Trenker R, Call ME*, Call MJ*. Crystal Structure of the Glycophorin A Transmembrane Dimer in Lipidic Cubic Phase. J Am Chem Soc. 2015 Dec 23;137(50):15676-9. PMID: 26642914
- Knoblich K, Park S, Lutfi M, van ’t Hag L, Conn CE, Seabrook SA, Newman J, Czabotar PE, Im W, Call ME* and Call MJ*. Transmembrane complexes of DAP12 crystallized in lipid membranes provide novel insights into control of oligomerization in immunoreceptor assembly. Cell Rep. 2015 May 26;11(8):1184-92 PMID: 25981043
- Berry R, Headey SJ, Call MJ, McCluskey J, Tregaskes CA, Kaufman J, Koh R, Scanlon MJ, Call ME & Rossjohn J. Structure of the chicken CD3epsilondelta/gamma heterodimer and its assembly with the alphabetaT cell receptor. J Biol Chem 2014. 289, 8240-8251 PMID:3961652