Misty Jenkins-Projects

Misty Jenkins-Projects

Researcher: 

Projects

Investigating the generation of dual-specific anti-tumour CAR T responses

In this project, we are investigating the rules of engagement for dual-specific CAR T cells. We are studying the signalling requirements for an effective dual-specific T cells response to cancer, and understanding the trafficking and establishment of memory CAR T cells.

Team members: Hannah Hughes-Perry, Dr Ryan Cross

Generating tumour specific CAR T cells for immunotherapy treatment of paediatric diffuse midline glioma

In this project, we have generated novel tumour-specific CAR T cells to treat paediatric glioma and are currently testing these in vitro and in vivo

Team members: Dr Shiqi Stacie Wang, Dr Ryan Cross

Investigating the role of co-stimulation in the activation of T cells and Chimeric Antigen Receptor T cell design

In this project, we are researching the role of co-stimulation in T cell activation. With a better understanding of T cell biology and CAR T cell biology we can provide a foundation in which a fine-tuned CAR design can be constructed to provide safer and more effective treatments for targeted immunotherapy. 

Team members: Terri Scanlon, in collaboration with Dr Susanne Heinzel and Professor Phil Hodgkin

Generating tumour specific CAR T cells for immunotherapy treatment of adult glioblastoma

In this project, we have generated novel tumour-specific CAR T cells to treat adult glioblastoma and are currently testing these in vitro and in vivo.

Team members: Bec Abbott, Dr Ryan Cross