Rosie Watson-Projects

Rosie Watson-Projects

Projects

The Lewy Body Study

Lewy body dementia, which includes Parkinson’s disease dementia and dementia with Lewy bodies, is the second commonest form of neurodegenerative dementia after Alzheimer’s disease. A devastating and progressive illness, Lewy body dementia is associated with higher rates of morbidity, dependency, and mortality than Alzheimer’s disease. Diagnostic accuracy is challenging, and delayed diagnosis and misdiagnosis remain common.

The Lewy Body Study is an observational longitudinal multicentre clinical and biomarker study aimed at investigating the influence of proteinopathies and vascular impairments on disease trajectory and outcome in patients with Lewy body dementia.

Team members

  • Lesley Vidaurre

  • Dr Kai Sin Chin

  • Associate Professor Nawaf Yassi

  • Jacqueline Hayem

SIMOA Platform

The SIMOA-HDX technology is a highly sensitive and automated biomarker platform which allows for the detection of proteins associated with dementia pathology in blood and other body fluids (e.g. spinal fluid).

The detection of blood biomarkers such as neurofilament light chain, amyloid-b and tau represents a major potential advance in the field of dementia, opening up the possibility of a blood test for dementia diagnosis.

The SIMOA platform is also available for research collaborations in other neurological and non-neurological diseases.

Team members

  • Dr Katharina Stracke

  • Associate Professor Nawaf Yassi

COBALT – COmBining Memantine And cholinesterase inhibitors in Lewy body dementia treatment Trial

In a collaborative, investigator initiated and led clinical trial supported by NIHR (UK) and NHMRC we aim to assess the clinical and cost-effectiveness of memantine compared to placebo in patients with dementia with Lewy bodies (DLB) and patients with Parkinson’s disease dementia (PDD) already taking an acetylcholinesterase inhibitor.

Recruitment will commence in 2021.

Project resources

Team members

  • Nawaf Yassi

  • Lesley Vidaurre