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- A new regulator of stemness to create dendritic cell factories for immunotherapy
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- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
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- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
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- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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Sant-Rayn Pasricha-Publications
Researcher:
Selected publications
- Pasricha SR, Lim PJ, Duarte T, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost J, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper S, Ashley N, Soilleux E, Olinga P, Muckenthaler M, Hughes J, Rivella S, Milne TA, Armitage AE, Drakesmith AH. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z. PMID: 28864822
- Wray K, Allen A, Evans E, Fisher C, Premawardhena A, Perera L, Rodrigo R, Goonathilaka G, Ramees L, Webster C, Armitage AE, Prentice AM, Weatherall DJ*, Drakesmith H*, Pasricha SR*. Hepcidin detects iron deficiency in Sri Lankan adolescents with a high burden of hemoglobinopathy: a diagnostic test accuracy study. Am J Hematol 2016 Nov 24. doi: 10.1002/ajh.24617. PMID: 27883199
- Armitage AE, Lim PJ, Frost JN, Pasricha SR, Soilleux EJ, Evans E, Morovat A, Santos A, Diaz R, Biggs D, Davies B, Gileadi U, Robbins PA, Lakhal-Littleton S, Drakesmith H. Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia. J Innate Immun. 2016;8(5):517-28. PMID: 27423740
- Pasricha SR, McHugh K, Drakesmith H. Regulation of hepcidin by erythropoiesis – the story so far. Annual Rev Nutr. 2016 Jul 17;36:417-34 PMID: 27146013
- Jones E,* Pasricha SR,* Allen A, Evans P, Fisher CA, Wray K, Premawardhena A, Bandara D, Perera A, Webster C, Sturges P, Olivieri NF, St Pierre T, Armitage AE, Porter JB, Weatherall DJ*, Drakesmith H*. Blood. 2015 Jan 29;125(5):873-80. doi: 10.1182/blood-2014-10-606491. PMID: 25519750
- Pasricha SR*, Atkinson SH,* Armitage AE, Khandwala S, Veenemans J, Cox SE, Eddowes LA, Hayes T, Doherty CP, Demir AY, Tijhaar E, Verhoef H, Prentice AM*, Drakesmith H*. Expression of the iron hormone hepcidin distinguishes types of anemia in African children. Sci Transl Med. 2014 May 7;6(235):235re3. doi: 10.1126/scitranslmed.3008249. PMID: 24807559
- Pasricha SR, Hayes E, Kalumba KK, Biggs BA. Effects of daily iron supplementation on health in 4-23 month old children: systematic review and meta-analysis of randomized controlled trials. Lancet Glob Health. 2013 Aug;1(2):e77-86. doi: 10.1016/S2214-109X(13)70046-9. Epub 2013 Jul 24. PMID: 25104162
- Pasricha SR, Frazer DM, Bowden DK, Anderson GJ. Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with beta-thalassemia major - a longitudinal study. Blood. 2013 Jul 4;122(1):124-33. doi: 10.1182/blood-2012-12-471441. Epub 2013 May 8. PMID: 23656728
- Pasricha SR, Drakesmith H, Black J, Hipgrave D, Biggs BA. Control of iron deficiency anemia in low and middle-income countries. Blood 2013 Apr 4;121(14):2607-17. doi: 10.1182/blood-2012-09-453522. Epub 2013 Jan 25 PMID: 23355536
- Pasricha SR, Black J, Muthayya S, Shet A, Bhat V, Nagaraj S, Prashanth NS, Sudarshan H, Biggs BA, Shet AS. Determinants of anemia among children in rural India. Pediatrics. 2010 Jul;126(1):e140-e149 PMID: 20547647