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- Alistair Brown
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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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- WEHI.TV
WHO Collaborating Centre for Anaemia Detection and Control
Researcher:
WHO Collaborating Centre for Anaemia Detection and Control
WEHI has been designated as the World Health Organization (WHO) Collaborating Centre for Anaemia Detection and Control.
Our anaemia researchers will support the WHO on the best approaches to diagnose and treat anaemia, including preventing iron deficiency.
A global problem
is leading studies into the use of iron supplements to
prevent anaemia in mothers and children.
Two billion people worldwide – including around a million Australians – are anaemic, meaning they have abnormally low levels of oxygen-carrying red blood cells or haemoglobin in their blood. Anaemia is especially prevalent in low-income countries.
Anaemia can have serious short- and long-term health consequences. These include fatigue, heart problems and susceptibility to certain infections such as malaria. Anaemia in pregnant women or young children can increase their susceptibility to pregnancy-associated complications, and can cause long-term developmental problems for the child.
Iron deficiency is the main cause of anaemia, but both conditions can be caused by a range of other health issues including cancer, inflammatory conditions and coeliac disease. Reducing the prevalence of iron deficiency is critical for many of the WHO’s Global Targets 2025, particularly around improving women’s and children’s health.
Improving health by combatting anaemia
The WHO Collaborating Centre for Anaemia Detection and Control enlists WEHI researchers into the WHO’s efforts to reduce anaemia. Our researchers provide the most up-to-date, evidence-based advice to WHO, to ensure global programs to combat anaemia are effective and relevant to the unique circumstances of different countries.
The WHO Collaborating Centre for Anaemia Detection and Control is led by Professor Sant-Rayn Pasricha, a clinician-scientist and haematologist.
Professor Pasricha leads international trials of iron interventions as a treatment for iron-deficiency anaemia in low-income countries. His laboratory also investigates how iron levels are controlled at the molecular level.
Super Content:
Institute researchers have launched one of the largest international efforts to prevent and treat maternal anaemia in developing countries.
The study will also investigate the impacts of iron deficiency on the developing infant brain.