Shabih Shakeel-Projects

Shabih Shakeel-Projects



Mechanism of heterochromatin formation

Heterochromatin formation in a specific region of the genome leads to its inactivation. Such physical alteration of our DNA without changing the underlying genetic code is a complex process undertaken by large protein complexes. Our lab investigates how such large protein complexes perform this function. 

Mechanism of DNA repair in heterochromatin regions of genome

Double-stranded DNA breaks in heterochromatin are repaired by a process of homologous recombination by exchange of genetic material between two sister chromatids. Our lab investigates how this process works in highly repetitive regions of heterochromatin without leading to fragile chromosomes.