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- A new regulator of 'stemness' to create dendritic cell factories for immunotherapy
- Advanced imaging interrogation of pathogen induced NETosis
- Cancer driver deserts
- Cryo-electron microscopy of Wnt signalling complexes
- Deciphering the heterogeneity of breast cancer at the epigenetic and genetic levels
- Developing drugs to block malaria transmission
- Developing new computational tools for CRISPR genomics to advance cancer research
- Developing novel antibody-based methods for regulating apoptotic cell death
- Discovering novel paradigms to cure viral and bacterial infections
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Do membrane forces govern assembly of the deadly apoptotic pore?
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- E3 ubiquitin ligases in neurodegeneration, autoinflammation and cancer
- Engineering improved CAR-T cell therapies
- Epigenetic biomarkers of tuberculosis infection
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- Genomic rearrangement detection with third generation sequencing technology
- How does DNA damage shape disease susceptibility over a lifetime?
- How does DNA hypermutation shape the development of solid tumours?
- How platelets prevent neonatal stroke
- Human lung protective immunity to tuberculosis
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of dysregulated Tom40 in neurodegeneration
- Investigating the role of mutant p53 in cancer
- Lupus: proteasome inhibitors and inflammation
- Machine learning methods for somatic genome rearrangement detection
- Malaria: going bananas for sex
- Measurements of malaria parasite and erythrocyte membrane interactions using cutting-edge microscopy
- Measuring susceptibility of cancer cells to BH3-mimetics
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Mutational signatures of structural variation
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Revealing the epigenetic origins of immune disease
- Reversing antimalarial resistance in human malaria parasites
- Structural and functional analysis of DNA repair complexes
- Targeting human infective coronaviruses using alpaca antibodies
- Towards targeting altered glial biology in high-grade brain cancers
- Uncovering the real impact of persistent malaria infections
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding how malaria parasites sabotage acquisition of immunity
- Understanding malaria infection dynamics
- Understanding the mechanism of type I cytokine receptor activation
- Unveiling the heterogeneity of small cell lung cancer
- Using alpaca antibodies to understand malaria invasion and transmission
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to cross the blood brain barrier for drug delivery
- Using structural biology to understand programmed cell death
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Stephen Nutt-Projects
Researcher:
Harnessing the power of dendritic cells
Dendritic cells (DCs) are key sentinels that are found throughout the body and act to stimulate protective immune responses against pathogens or cancers. To better tailor the immune response to the challenge at hand, DCs have evolved into multiple anatomically and functionally distinct cell types that form an interface between the external environment and the adaptive immune system. We aim to better understand how this DC diversity is programmed on a transcriptional level as well as to devise approaches to better harness the immune stimulatory properties of DCs to promote key functions such as anti-tumour immunity.
Team members: Dr Michaël Chopin, Shengbo Zhang, Angela D’Amico
The production of antibodies
Antibodies are an essential element of the immune response to infection and underpin the success of current vaccination strategies. Antibodies are produced by plasma cells, the terminally differentiated cells of the B lymphocyte lineage. We are interested in the biological process producing B lymphocytes and plasma cells, as well as the sources of diversity within the immune response. An improved understanding of the production of antibodies will not only provide new approaches to improve vaccination strategies but also provide insights into why this process sometimes goes awry, resulting in autoimmune diseases and the formation of blood cell cancers.
Team members: Dr Julie Tellier, Dr Caleb Dawson, Dr Ashley Ng, Junli Nie, Ladina Di Rago.
Developing new approaches to treat multiple myeloma
Multiple myeloma is a malignancy of antibody-secreting plasma cells and is one of the most common blood cancers. Despite considerable treatment advances in recent years, many patients relapse, and the disease remains incurable. We aim to use genetic models and human multiple myeloma material to develop new treatment options for multiple myeloma patients.
Team members: Dr Simon Willis, Dr Melissa Holmes, Jacob Jackson.
Elucidating neuroimmune interactions: novel strategies for treatment of chronic diseases
Chronic inflammatory diseases have common pathogenic features of dysregulated immune responses. However, the events leading to this dysregulation are not well understood. The maintenance of mucosal homeostasis requires sensory circuits to continually survey mucosal tracts for perturbations in microbial, dietary, and environmental cues.
In this project, we are mapping the interactions between the nervous and immune systems to establish their roles in the maintenance of tissue homeostasis and control of inflammation. An understanding of these pathways will form the basis for exploiting neuronal circuits to promote homeostatic function of immune cells and inform novel therapeutic strategies for inflammatory diseases.
Project resources
Gut reaction: how immunity ramps up against incoming threats
Gut reaction: eating causes spike in immunity
Team members: Dr Cyril Seillet, Le Xiong