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- A new regulator of 'stemness' to create dendritic cell factories for immunotherapy
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- Deciphering the heterogeneity of breast cancer at the epigenetic and genetic levels
- Developing drugs to block malaria transmission
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- Do membrane forces govern assembly of the deadly apoptotic pore?
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- E3 ubiquitin ligases in neurodegeneration, autoinflammation and cancer
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- Finding treatments for chromatin disorders of intellectual disability
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- How does DNA damage shape disease susceptibility over a lifetime?
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- How platelets prevent neonatal stroke
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- Revealing the epigenetic origins of immune disease
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- Structural and functional analysis of DNA repair complexes
- Targeting human infective coronaviruses using alpaca antibodies
- Towards targeting altered glial biology in high-grade brain cancers
- Uncovering the real impact of persistent malaria infections
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding how malaria parasites sabotage acquisition of immunity
- Understanding malaria infection dynamics
- Understanding the mechanism of type I cytokine receptor activation
- Unveiling the heterogeneity of small cell lung cancer
- Using alpaca antibodies to understand malaria invasion and transmission
- Using combination immunotherapy to tackle heterogeneous brain tumours
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Stephin Vervoort - Publications
Researcher:
Selected publications
- SJ Vervoort*a, SA Welsh*, JR Devlin, E Barbieri, DA Knight, M Costacurta I Todorovski, CJ Kearney, J Sandow, S Bjelosevic, Z Fan, J Visser, K Pavic, B Martin, G Gregory, SJ Hogg, M Kelly, A Newbold, K Simpson, O Kauko, K Harvey, M Ohlmeyer, J Westermarck, N Gray, A Gardini#a, R.W. Johnstone#ab, The PP2A-Integrator-CDK9 axis fine tunes transcription and can be targeted therapeutically in cancer. Cell 2021. PMID: 34004147 DOI: 10.1016/j.cell.2021.04.022. *Co-corresponding and first author.
- Simon J. Hogg, Olga Motorna, Leonie A. Cluse, Timmothy M. Johanson, Hannah D. Coughlan, Ramya Raviram, Robert M. Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N. Huskins, Conor J. Kearney, Jennifer R. Devlin, Zheng Fan, Jafar S. Jabbari, Ben P. Martin, Mohamed Fareh, Madison J. Kelly, Daphné Dupéré-Richer, Jarrod J. Sandow, Breon Feran, Deborah Knight, Tiffany Khong, Andrew Spencer, Simon J. Harrison, Gareth Gregory, Vihandha O. Wickramasinghe, Andrew I. Webb, Phillippa C. Taberlay, Kenneth D. Bromberg, Albert Lai, Anthony T. Papenfuss, Gordon K. Smyth, Rhys S. Allan, Jonathan D. Licht, Dan A. Landau, Omar Abdel-Wahab, Jake Shortt, Stephin J. Vervoort†*, Ricky W. Johnstone†*. Targeting P300/CBP reveals discrete regulation of transcription and chromatin accessibility by histone acetylation. Molecular Cell 2021. DOI: 10.1016/j.molcel.2021.04.015. *Co-senior and Co-corresponding authors
- Kearney CJ*, Vervoort SJ*, Ramsbottom KM, Todorovski I, Lelliott EJ, Zethoven M, Pijpers L, Martin BP, Semple T, Martelotto L, Trapani JA, Parish IA, Scott NE, Oliaro J, Johnstone RW. SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells. Science Advances. 2021 Feb 19;7(8):eabe3610. doi: 10.1126/sciadv.abe3610. PMID: 33608275; PMCID: PMC7895430. *Co-first author
- Emily J Lelliott, Isabella Y Kong, Magnus Zethoven, Kelly M Ramsbottom, Luciano G. Martelotto, Deborah Meyran, Joe Jiang Zhu, Matteo Costacurta, Laura Kirby, Jarrod J Sandow, Lydia Lim, Pilar M Dominguez, Izabela Todorovski, Nicole M Haynes, Paul A. Beavis, Paul J Neeson, Edwin D Hawkins, Grant A McArthur, Ian A Parish, Ricky W. Johnstone, Jane Oliaro, Karen E Sheppard*, Conor J Kearney* and Stephin J Vervoort*. CDK4/6 inhibition promotes anti-tumor immunity through the induction of T cell memory. Cancer Discovery 2021. PMID: 33990344 Doi: 10.1158/2159-8290.CD-20-1554. *Co-senior and corresponding
- Kong IY, Rimes JS, Light A, Todorovski I, Jones S, Morand E, Knight DA, Bergman YE, Hogg SJ, Falk H, Monahan BJ, Stupple PA, Street IP, Heinzel S, Bouillet P, Johnstone RW, Hodgkin PD, Vervoort SJ*, Hawkins ED*. Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation. Cell Rep. 2020 Oct 20;33(3):108290. doi: 10.1016/j.celrep.2020.108290. PMID: 33086063. *Co-senior and corresponding author
- Fan Z, Devlin JR, Hogg SJ, Doyle MA, Harrison PF, Todorovski I, Cluse LA, Knight DA, Sandow JJ, Gregory G, Fox A, Beilharz TH, Kwiatkowski N, Scott NE, Vidakovic AT, Kelly GP, Svejstrup JQ, Geyer M, Gray NS, Vervoort SJ*, Johnstone RW*. CDK13 cooperates with CDK12 to control global RNA polymerase II processivity. Sci Adv. 2020 Apr 29;6(18):eaaz5041. doi: 10.1126/sciadv.aaz5041. PMID: 32917631; PMCID: PMC7190357. *Co-senior and corresponding author
- Kelly MJ, So J, Rogers AJ, Gregory G, Li J, Zethoven M, Gearhart MD, Bardwell VJ, Johnstone RW, Vervoort SJ*, Kats LM*. Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis. Nature Communications. 2019 Mar 22;10(1):1347. doi: 10.1038/s41467-019-09250-6. PMID: 30902969; PMCID: PMC6430802. *Co-senior authors
- Vervoort SJ, de Jong OG, Roukens MG, Frederiks CL, Vermeulen JF, Lourenço AR, Bella L, Vidakovic AT, Sandoval JL, Moelans C, van Amersfoort M, Dallman MJ, Bruna A, Caldas C, Nieuwenhuis E, van der Wall E, Derksen P, van Diest P, Verhaar MC, Lam EW, Mokry M, Coffer PJ. Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis. Elife. 2018 Dec 3;7:e27706. doi: 10.7554/eLife.27706. PMID: 30507376; PMCID: PMC6277201.
- Kearney CJ*, Vervoort SJ*, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J. Tumor immune evasion arises through loss of TNF sensitivity. Sci Immunol. 2018 May 18;3(23):eaar3451. doi: 10.1126/sciimmunol.aar3451. PMID: 29776993. *Co-first authors
- Vervoort SJ, Lourenço AR, Tufegdzic Vidakovic A, Mocholi E, Sandoval JL, Rueda OM, Frederiks C, Pals C, Peeters JGC, Caldas C, Bruna A, Coffer PJ. SOX4 can redirect TGF-β-mediated SMAD3- transcriptional output in a context-dependent manner to promote tumorigenesis. Nucleic Acids Res. 2018 Oct 12;46(18):9578-9590. doi: 10.1093/nar/gky755. PMID: 30137431; PMCID: PMC6182182.
Super Content:
Dr Stephin Vervoort has received a prestigious fellowship from the Snow Medical Research Foundation to investigate new treatment options for cancers such as leukaemia.
Dr Stephin Vervoort has been awarded a CSL Centenary Fellowship to fund his research to find new treatments for leukaemia and other types of cancers.