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About

I am interested in the field of gene-editing and the generation of mouse models. Our group has used CRISPR gene-editing technology to generate highly complex mouse models and we are currently investigating the use of various CRISPR enzymes to increase the efficiency and speed of generating these models.

Publications

Selected publications from Dr Andrew Kueh

Kauppi M, Hyland CD, Viney EM, White CA, de Graaf CA, Welch AE, Yousef J, Dagley LF, Emery-Corbin SJ, Di Rago L, Kueh AJ, Herold MJ, Hilton DJ, Babon JJ, Nicola NA, Behrens K, Alexander WS. Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice. Blood. 2025;145(10):10.1182/blood.2024025406

Swiderski K, Trieu J, Chee A, Naim T, Brock CJ, Baum DM, Chan AS, Hardee JP, Li W, Kueh AJ, Herold MJ, Murphy KT, Gregorevic P, Lynch GS. Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia. Life Sciences. 2025;362:10.1016/j.lfs.2024.123343

Bidgood GM, Keating N, Guzman LM, Li K, Leong E, Kueh A, Babon JJ, Hockings C, Doggett K, Nicholson SE. The Ability of SOCS1 to Cross-Regulate GM-CSF Signaling is Dose Dependent. Journal of Interferon & Cytokine Research. 2025;45(2):10.1089/jir.2024.0140

Jex A, John N, McCarthy D, Myers S, Begue N, Schang C, Usher SP, Baker L, Kaucner C, Monis P, Hartman LM, Flynn B, Merrett JE, Lister D, Herold M, Kueh A, Cheng NN, Nolan J, Caly L, Druce J, Thorley B, Scales PJ, Schmidt J, Sarkis S, Crosbie ND, Poon R, Nolan M. Multi-tiered strategy for large-scale wastewater detection of SARS-CoV-2 in low-case settings provides confidence for public health actions. Journal of Water and Health. 2025;23(2):10.2166/wh.2025.164

Jin W, Deng Y, La Marca JE, Lelliott EJ, Diepstraten ST, König C, Tai L, Snetkova V, Dorighi KM, Hoberecht L, Hedditch MG, Whelan L, Healey G, Fayle D, Lau K, Potts MA, Chen MZ, Johnston APR, Liao Y, Shi W, Kueh AJ, Haley B, Fortin J-P, Herold MJ. Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening. Nature Communications. 2025;16(1):10.1038/s41467-025-56282-2

Schulz SR, Menzel SR, Wittner J, Ulbricht C, Grofe AT, Roth E, Mann-Nüttel R, Scheu S, Kueh AJ, Jäck A, Herold MJ, Hauser AE, Pracht K, Schuh W, Jäck H-M. Decoding plasma cell maturation dynamics with BCMA. Frontiers in Immunology. 2025;16:10.3389/fimmu.2025.1539773

McCulloch TR, Rossi GR, Alim L, Lam PY, Wong JKM, Coleborn E, Kumari S, Keane C, Kueh AJ, Herold MJ, Wilhelm C, Knolle PA, Kane L, Wells TJ, Souza-Fonseca-Guimaraes F. Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation. Nature Communications. 2024;15(1):10.1038/s41467-024-54232-y

Cheung BB, Mittra R, Murray J, Wang Q, Seneviratne JA, Raipuria M, Wong IPL, Restuccia D, Gifford A, Salib A, Sutton S, Huang L, Ferdowsi PV, Tsang J, Sekyere E, Mayoh C, Luo L, Brown DL, Stow JL, Zhu S, Young RJ, Solomon BJ, Chappaz S, Kile B, Kueh A, Herold MJ, Hilton DJ, Liu T, Norris MD, Haber M, Carter DR, Parker MW, Marshall GM. Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Communications Biology. 2024;7(1):10.1038/s42003-024-06899-8

Lieschke E, Thomas AF, Kueh A, Atkin-Smith GK, Baldoni PL, La Marca JE, Young S, Huang AS, Ross AM, Whelan L, Kaloni D, Tai L, Smyth GK, Herold MJ, Hawkins ED, Strasser A, Kelly GL. Mouse models to investigate in situ cell fate decisions induced by p53. The EMBO Journal. 2024;43(19):10.1038/s44318-024-00189-z

Swiderski K, Naim T, Trieu J, Chee A, Herold MJ, Kueh AJ, Goodman CA, Gregorevic P, Lynch GS. Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles. Physiological Reports. 2024;12(13):10.14814/phy2.16145

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