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About

Ben leads the Genito-Urinary (GU) research program within the Gibbs Lab at WEHI. His team focuses on generating Real World Evidence (RWE) to change practice in GU cancers.

Ben is also a medical oncologist at Peter MacCallum Cancer Centre where he leads the GU medical oncology group and trials program. He is an Associate Professor at the University of Melbourne. Ben also chairs the Phase 1 Trials Group within Cancer Trials Australia and the Germ Cell Tumour group within ANZUP.

At WEHI, Ben leads multi-national registries in Prostate cancer, Urothelial cancer, Testis cancer and Kidney cancer. Data from these registries have been utilized to describe treatment patterns, identify clinical and tissue-based biomarkers and inform future research strategies. Ben has expanded the out-reach of these registries to Asia, with sites now contributing from Singapore and Korea. Ben is recognized globally for his leadership in RWE in GU cancers. Ben is also internationally recognized as an expert in testicular cancer, utilizing his RWE leadership to drive pragmatic clinical trials aimed at improving long term outcomes for testicular cancer survivors.

Ben also leads the early development of novel therapeutics in GU cancers. He is globally respected for his knowledge and expertise in early phase, first time in human clinical trials. His role within developmental therapeutics is essential in connecting scientists to clinicians and facilitating a bench to bedside and back to bench approach to cancer research.

Publications

Selected publications from A/Prof Ben Tran

Conduit C, Hutchinson AD, Leonard M, O.’Haire S, Moody M, Thomas B, Sim I, Hong W, Ahmad G, Lawrentschuk N, Lewin J, Tran B, Dhillon HM. An exploration of testicular cancer survivors’ experience of ejaculatory dysfunction following retroperitoneal lymph node dissection—a sub-study of the PREPARE clinical trial. Journal of Cancer Survivorship. 2025;19(2):10.1007/s11764-023-01489-9

Eifer M, Sutherland DEK, Goncalves I, Buteau JP, Au L, Azad AA, Emmett L, Kong G, Kostos L, Ravi Kumar AS, Kwan EM, Medhurst E, Sandhu S, Tran B, Wyatt AW, Hofman MS. Therapy-Related Myeloid Neoplasms After [177Lu]Lu-PSMA Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Series.Journal of Nuclear Medicine. 2025;66(4):10.2967/jnumed.124.268640

Udovicich C, Bressel M, Manji J, Ali M, Au L, Azad AA, Buteau JP, Chander S, Chang D, Eapen R, Lawrentschuk N, Levy SM, Moon D, Murphy DG, Perera M, Shaw M, Spain L, Tran B, Hofman MS, Siva S. PSMA-Guided Metastasis-Directed Therapy for Oligometastatic Renal Cell Carcinoma: The Proof-of-Concept PEDESTAL Study.Journal of Nuclear Medicine. 2025;66(4):10.2967/jnumed.124.268639

Kostos L, Buteau JP, Kong G, Tran B, Haskali MB, Fahey M, Crumbaker M, Emmett L, Hofman MS, Azad AA. Clinical Trial Protocol for LuCAB: A Phase I-II Trial Evaluating Cabazitaxel in Combination with [177Lu]Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer.Journal of Nuclear Medicine. 2025;66(4):10.2967/jnumed.124.269252

Abdul Aziz N, Ng K, Alifrangis C, Tran B, Conduit C, Liow ECH, Ackerman C, Georgescu R, Jamal T, Relton C, Mayer E, Nicol D, Cazzaniga W, Huddart RA, Reid AH, Shamash J, Rajan P. THERATEST: A multi-centre observational cohort feasibility study of de-escalation therapies for stage II seminoma.Journal of Clinical Oncology. 2025;43(5_suppl):10.1200/jco.2025.43.5_suppl.tps651

Hansen AR, Zhang AY, Boni V, Mantia C, Yu EY, Weickhardt AJ, Robert M, Gupta S, Morales-Barrera R, Hoimes CJ, Berlin J, Iyer G, Millward M, Lihou CF, Loriot Y, Pouessel D, Mittal K, Hill AG, Racca F, Tran B. A multicenter, open-label phase 1/2 study of TYRA-300 in advanced urothelial carcinoma and other solid tumors with activating FGFR3 alterations (SURF301).Journal of Clinical Oncology. 2025;43(5_suppl):10.1200/jco.2025.43.5_suppl.tps904

Mak B, Tran B, Thomas H, Pashankar FD, Hansen AR, Feldman DR, Huddart RA, Wheater M, Dunwoodie E, Mazhar D, Lawrence NJ, Stevanovic AG, Birtle AJ, Oladipo O, Wyld D, Balagtas JMS, Stockler MR, Grimison PS. P3BEP (ANZUP 1302): An international randomized phase 3 trial of accelerated versus standard BEP chemotherapy for individuals aged 11-50 years with intermediate and poor-risk metastatic germ cell tumours (GCTs).Journal of Clinical Oncology. 2025;43(5_suppl):10.1200/jco.2025.43.5_suppl.tps653

Liu J, Hiwase M, Woon DTS, Thomas B, Tran B, Lawrentschuk N. Primary retroperitoneal lymph node dissection in stage II testicular seminoma: a systematic review. BJU International. 2025;135(2):10.1111/bju.16536

Panian J, Zhong C, Choi SH, Ly K, Quinn R, Ferrier E, Saad E, Saliby RM, Malvar C, Pal S, Ebrahimi H, Tran B, Jude E, Lalani A-K, Suarez C, Velasco GD, Kanesvaran R, Zarba M, Liow E, El Hajj Chehade R, Choueiri TK, Heng DYC, McKay RR. Efficacy of Treatments After Lenvatinib in Patients with Advanced Renal Cell Carcinoma. European Urology Focus. 2024;:10.1016/j.euf.2024.11.011

Hitchen N, Shahnam A, Manoharan S, Topp M, Mileshkin L, Lim AM, Whittle JR, Luen SJ, Solomon B, Lackovic K, Desai J, Tran B. Trends in phase 1 oncology clinical trials across Australia; Analysis of ClinicalTrials.gov 2012–2022. Asia-Pacific Journal of Clinical Oncology. 2024;20(6):10.1111/ajco.14100

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