Sindhuja Sridharan - EMBL

Sindhuja Sridharan - EMBL

Location: 
Online
Start Time: 
Tue, 22/06/2021 - 4:00pm
End Time: 
Tue, 22/06/2021 - 5:00pm

WEHI Special Lecture hosted by Associate Professor Andrew Webb

 

Sindhuja Sridharan, PhD

Postdoctoral Fellow, European Molecular Biology Laboratory (EMBL), Germany


 

The many roles of ATP and protein phosphorylation in cellular organization

 

 

Join via TEAMS

Including Q&A session





Sindhuja Sridharan is a postdoctoral fellow in Mikhail Savitski’s team at EMBL, Germany. She develops proteomics technologies such as thermal proteome profiling (TPP or MS-CETSA) and solubility proteome profiling (SPP) to uncover functional roles of protein-metabolite interactions in biology and disease. In her recent work, she and her colleagues have quantified the proteome-wide interactions of ATP using TPP and uncovered a new function of this crucial metabolite in solubilizing proteins that assemble into biomolecular condensates. These assemblies are highly dynamic micron scale structures that condense proteins and nucleic acids to perform various cellular functions including RNA metabolism, ribosome biogenesis, DNA damage response and signal transduction. In a subsequent work, Sindhuja and her team have elucidated the wide-spread role of protein phosphorylation in regulation of biomolecular condensate assembly.

 

Sindhuja studied biotechnology at SASTRA university, India. She obtained her PhD in Biological Science from the National University of Singapore, where she investigated and designed peptide therapeutics with cardiovascular properties from snake venom. She is currently in Germany pursuing her postdoctoral research since 2016.

 

All welcome!