Development of tau-specific therapeutic and diagnostic antibodies

Development of tau-specific therapeutic and diagnostic antibodies

Project details

The protein Tau is expressed within neurons and helps stabilise microtubules. In Alzheimer’s disease, a disease for which there is currently no cure or simple diagnostic test, Tau becomes abnormally modified and aggregates within neurons. This ultimately results in neuronal toxicity and degeneration. An increase in modified Tau is also detected in the blood of patients with Alzheimer’s disease. Tau is therefore a highly attractive therapeutic and diagnostic target.

This project aims to generate novel and highly specific monoclonal antibodies, small antibody fragments and nanobodies against modified forms of Tau that are increased in disease and characterise their binding and functionality. The project will utilise molecular biology techniques (cloning), biochemical techniques (protein expression, protein purification and western blotting) and well as in vitro cell assays and immunoassays.

About our research group

This project will take place in the Watson/Yassi lab under the primary supervision of Dr Rebecca Nisbet. The vision of the Watson/Yassi lab is to develop an interdisciplinary approach to dementia research and care. The focus of our lab it to improve dementia diagnosis, investigate midlife risk factors that may better inform prevention strategies; establish and support dementia cohorts and facilitate investigator-led clinical trials.

Dr Nisbet has a long-standing interest in the generation and characterisation of novel tau antibodies as therapeutics for the treatment of Alzheimer’s disease and employing innovative strategies to enhance their delivery into the brain. Previous work in her team has demonstrated that tau antibodies and small antibody fragments are able reduce disease pathology and restore behavior in vivo.

Researchers:

Dr Rebecca Nisbet
Dr
Rebecca
Nisbet
Population Health and Immunity division

Associate Professor Nawaf Yassi

Associate Professor Nawaf Yassi
Associate Professor
Nawaf
Yassi
Joint Laboratory Head

Associate Professor Rosie Watson

Associate Professor Rosie Watson
Associate Professor
Rosie
Watson
Joint Laboratory Head

Project Type: