Evolution of haematopoiesis in vertebrates

Evolution of haematopoiesis in vertebrates

Project details

The major hematopoietic lineages have existed since early in vertebrate evolution, covering the key functions of oxygen transport, clotting and defense against infection, yet the details of how these functions are performed are unique to mammals.

Using single cell transcriptomes, we have profiled the gene expression from mammals to early vertebrates. You will use this data to search for genes which are associated with mammalian specific processes such as polyploidy in megakaryocytes. These genes will be screened for function with an imaging based CRISPR screen, before follow up in vitro studies to confirm their role.

This project will involve both wet and dry lab techniques.

About our research group

Our laboratory studies the development and function of blood cells. We aim to identify genes and molecular pathways that are important in regulating normal blood cell production and understand the changes that lead to blood cell disorders such as autoimmune and inflammatory diseases, leukemia and lymphoma. We work with clinicians and industry partners to find better ways of treating these illnesses.

We take a multidisciplinary approach combining cell biology, physiology, biochemistry and molecular biology, genomics, bioinformatics and computational science to understand the blood cell system and its individual lineages. We also develop software that assists biologist in visualising and interacting with large data sets.

 

Email supervisors

 

Researchers:

Dr Carolyn de Graaf profile photo
Dr
Carolyn
de Graaf
Blood Cells and Blood Cancer division

Professor Doug Hilton

Professor Doug Hilton at the Institute
Professor
Doug
Hilton
Institute Director; Laboratory Head

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