High-resolution imaging of host cell invasion by the malaria parasite

High-resolution imaging of host cell invasion by the malaria parasite

Project details

Malaria is one of the deadliest diseases in the world, causing almost half a million deaths each year, among which a significant proportion are children. The design and development of effective vaccines or drug treatments against this devastating disease depends in part, on having a more detailed understanding about the mechanisms governing parasite interactions at the red blood cell membrane. In addition, more effective tools for interrogating such interactions would ensure a more rational design of new vaccine or drug candidates.

This project involves the use of high resolution, 3 and 4-dimensional microscopy techniques in two main areas of research. Firstly to establish an effective screening tool for interrogating host pathogen interactions and secondly, to decipher the molecular mechanisms and biophysical properties involved in host cell invasion. 

About our research group

This project is a collaboration between the Centre for Dynamic Imaging (CDI) and the Cowman Lab. The design and use of cutting edge imaging technologies will be led by Drs Kelly Rogers and Niall Geoghegan who have significant expertise in 3 and 4-dimensional microscopy, including Lattice light sheet microscopy. The CDI also has a range of confocal and super-resolution microscopy technologies. The work will be undertaken in collaboration with Prof. Alan Cowman and Dr Michal Pasternak. Prof. Cowman is an expert in the field of malaria parasite biology. 



Dr Kelly Rogers

Dr Kelly Rogers at a microscope
Division Head; Head, Centre for Dynamic Imaging

Professor Alan Cowman

Alan Cowman standing in a laboratory
Laboratory Head; Deputy Director, Science Strategy

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