How does DNA damage shape disease susceptibility over a lifetime?

How does DNA damage shape disease susceptibility over a lifetime?

Project details

As we age we gradually accumulate damage to our DNA. Over time, our tissues become dominated by cells that carry mutations that disrupt the pathways that control cell growth and survival. The link between DNA damage and cancer is well established, but there is growing evidence of a contribute to other diseases, including cardiovascular disease and inflammatory disorders. This project aims to accelerate the natural decay of the genome to determine how somatic mutations contribute to ageing and how this triggers disease. 

Genetic engineering will be used to manipulate DNA repair pathways. We will stimulate diverse forms of DNA damage and track their influence on clonal expansion and disease risk. Using these models we will study how real-world stresses, like cancer therapy or chronic inflammation modify patterns of clonal selection. 

About our research group

My research team investigates why cancers develop and how they change in response to therapy. Our primary strengths are in cancer genetics and genomics, with an emphasis on DNA repair. We use genomic approaches to study the genetic and epigenetic landscape of cancer, then we model these alterations in the laboratory to determine how they mediate their influence. 

Our laboratory has expertise that spans genetics, genomics, bioinformatics, haematology and cancer biology. We collaborate broadly and assemble expert teams to attack challenging questions. 

 

Email supervisors

 

Researchers:

Project Type: