How does DNA hypermutation shape the development of solid tumours?

How does DNA hypermutation shape the development of solid tumours?

Project details

This project will use novel genetic approaches to study the role of hypermutation in the development of bladder cancer. Cytidine deaminases from the APOBEC-family make a major contribution to the mutational landscape of cancers from the bladder, the breast and the lung. 

This project will develop a new model of bladder cancer by triggering high-level activation of APOBEC in defined cell populations within the bladder. We will investigate whether the high mutation burden accelerates tumour development and assess how this influences the immune environment within the cancer. Leveraging high-throughput genetic screening platforms, we will identify new ways to selectively target cells with high APOBEC activity. 

 

About our research group

My research team investigates why cancers develop and how they change in response to therapy. Our primary strengths are in cancer genetics and genomics, with an emphasis on DNA repair. We use genomic approaches to study the genetic and epigenetic landscape of cancer, then we model these alterations in the laboratory to determine how they mediate their influence. 

This collaborative project is run together with the Sutherland laboratory, who have developed many innovative models to study lung cancer biology. This project will build on this work to create new models of bladder cancer that more faithfully recapitulate the genomic landscape of the disease.  

 

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