The molecular controls on dendritic cell development

The molecular controls on dendritic cell development

Project details

Dendritic cells (DCs) are professional antigen-presenting cells, located throughout the body. They form the first line of defence against pathogens. To provide this protection DCs have evolved into specialised subsets that perform unique functions. Given their ability to initiate an adaptive response they hold great therapeutic potential, and therefore constitute an essential target in efforts to generate therapeutic immunity against cancer.

Our research aims to understand the molecular mechanisms underpinning DC diversity as these studies will pave the way to uncover novel approaches to alter DC fate to tailor DC-based therapeutic approaches.

Combining cellular, molecular biology, and high throughput technologies the candidate will investigate the role of novel transcription factors in governing DC fate.

About our research group

Our research aims to investigate how master regulators function on a cellular and molecular level to program the immune system. To address these questions we use:

  • Genetics
  • High-throughput genomic technologies
  • Infectious disease models 
  • Cell culture 

Email supervisors

 

Researchers:

Michael Chopin profile photo
Dr
Michael
Chopin
Immunology division

Project Type: