Molecular mechanisms of innate immune signalling

Molecular mechanisms of innate immune signalling

Project details

This project focuses on the NOD signalling pathway, which plays an important role in anti-bacterial immune responses. Recent research showed that the NOD pathway is deregulated in many inflammatory diseases such as Crohn’s disease, Multiple Sclerosis or Rheumatoid Arthritis, and therefore has gained the attention as a drug target. 
We have developed a NOD pathway inhibitor, which blocks inflammation and the progression of multiple sclerosis in preclinical models (Nachbur et al; Nat Comms 2015; 6:6442). 
This project will further dissect the molecular mechanisms of NOD signalling with the aim of identifying new drug targets for diseases with NOD involvement. The candidate will use a wide range of techniques to determine the role and function of NOD-associated proteins and develop new strategies to manipulate NOD signalling.  


About our research group

We are interested in how the NOD pathway contributes to inflammation and how we can stop the signalling process underlying inflammatory diseases. Therefore we have assembled an interdisciplinary team to dissect the NOD pathway on the molecular level.

The candidate will work at the interface between cell signalling, biochemistry and immunology. We are using an integral approach to determine the function and role of the NOD pathway in a range of diseases and we apply new knowledge in the field of cell signalling towards the development of new, anti-inflammatory drugs.




Ueli Nachbur in the lab
Cell Signalling and Cell Death division

Professor John Silke

John Silke
Joint Division Head

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