Revealing the epigenetic origins of immune disease

Revealing the epigenetic origins of immune disease

Project details

The epigenome controls cellular function by determining which genes are turned ‘on’ or ‘off’ within a cell, despite all cells in the body containing the same DNA code. The Allan lab aims to understand how epigenetic regulation controls immune cell development and function in health and disease. 

The particular project and approach will be tailored to the interests of the successful applicant but could involve: 

  • Characterising epigenetic drivers of immune diseases such as asthma and immunodeficiency 
  • Cell tracing approaches to determine the impact of the preexisting epigenetic landscape on immune cell function 

The successful applicant will develop advanced skills across immunology, molecular biology and genomics domains such as flow cytometry, RNA/ChIP/ATAC-seq, CUT&Tag, Hi-C techniques. The opportunity to develop computational skills in genomics data analysis is also available. 

About our research group

The Allan laboratory is a world-leading laboratory in the epigenetic regulation of immune cell function with particular expertise in 3D genome structure and epigenetic silencing mechanisms. 

We are a small (6 members) but highly productive and motivated lab group regularly publishing high-impact original research. e.g: 

  • Chan et al 2021 Nat Comms 12:1344 
  • Keenan et al 2020 Blood 135(23):2049-58  
  • Keenan et al 2019 JCI Insight 2019 4(10)e127745  
  • Johanson et al 2018 Nat Immunol 19(11):1257-64 
  • Allan et al 2012 Nature 487(7406):249-53 

We collaborative widely with researchers in diverse fields as well as with clinical colleagues at the Royal Melbourne Hospital. 

We also develop and hold important intellectual property to translate our research into the clinic. 

 

Email supervisors

 

Researchers:

Christine Keenan profile pic
Dr
Christine
Keenan
Immunology division

Project Type: