Revealing the role of the 3D genome organisation in leukaemia

Revealing the role of the 3D genome organisation in leukaemia

Project details

 

Leukaemia is caused by mutations in DNA. This project will explore how 3D DNA structure influences when and where these DNA mutations occur. There is an opportunity for a dedicated and enthusiastic student to join our team and reveal how 3D genome organisation influences the DNA mutations that cause leukaemia.  

A student with an interest in biology, programming and statistics would be able to work with genomic data sets to tackle biomedical problems centered around DNA structure and leukaemia. This could include: 

-novel pipeline development 

-analysis of the 3D structure through Hi-C techniques 

-transcriptomics analysis 

-variant analysis 

 

The student would work closely with both our bioinformatics postdocs and our wet lab team. This project could include some wet lab experience. 

 

About our research group

 

Every one of your nuclei contain 2 metres of DNA. We are fascinated by how this DNA is packed into the nucleus, and how this organisation changes throughout normal development and influences disease. Our team is small (lab head, 3x postdocs, 1x research assistant, 1x student) but enthusiastic and productive. Recently, we have published a number of high-impact publications (Nature Immunology, Nature Communications, among others). This success is due to our multidisciplinary team, containing expert molecular biologists and bioinformatians. After the graduation of our last student, we are looking for an enthusiastic bioinformatics student to join the team. If you are excited by using your mathematics/programming/statistics skills to reveal fundamental biological insights or change the way human disease is understood, please get in touch!

Email supervisors

 

Researchers:

Dr Tim Johanson
Dr
Tim
Johanson
Immunology division

Professor Gordon Smyth

Professor Gordon Smyth writing on a whiteboard
Professor
Gordon
Smyth
Joint Division Head
Dr Hannah Coughlan
Dr
Hannah
Coughlan
Bioinformatics division

Project Type: